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IPR016964 is a Sigma intracellular receptor 2.
<p>Sigma-2 receptor, also known as TMEM97, is an intracellular orphan receptor highly expressed in various rapidly proliferating cancer cells and regarded as a cancer cell biomarker. It is a cytochrome-related protein that binds to various pharmacological compounds, and modulates the cytosolic Ca2+ concentration, dopaminergic transmission, and cocaine-induced addiction behavior [[cite:PUB00086651], [cite:PUB00086652], [cite:PUB00086653]]. It may have a role as regulator of cellular cholesterol homeostasis [[cite:PUB00078073]] and function as a sterol isomerase [[cite:PUB00077739]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Transmembrane protein [Medicago truncatula] gi|357471215|ref|XP_003605892.1| | 14 | ||
| – | Transmembrane protein 97; TAIR: AT2G32380.1 Transmembrane protein 97, Putative; Swiss-Prot: sp|Q6DFQ5|TMM97_XENTR Transmembrane protein 97; TrEMBL-Plants: tr|I1LRR4|I1LRR4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0465400 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 50.00 |