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IPR017824 is a Aminodeoxychorismate lyase, class IV.
<p>Aminodeoxychorismate lyase (ADC lyase) converts aminodeoxychorismate to para-aminobenzoate during the process of tetrahydrofolate biosynthesis [[cite:PUB00002195]]. Tetrahydrofolate is an essential precursor for de novo purine biosynthesis. ADC lyase is a pyridoxal-phosphate-binding protein belonging to the class IV aminotransferase family. This entry also includes Bifunctional aminodeoxychorismate lyase / D-amino acid transaminase from Mycobacterium tuberculosis, which catalyses two enzymatic reactions in biochemically unrelated pathways: this protein acts as an aminodeoxychorismate (ADC) lyase (ADCL) in folate biosynthesis, converting 4-amino-4-deoxychorismate (ADC) to 4-aminobenzoate (PABA), and as a D-amino acid transaminase (DAAT) in peptidoglycan (PG) biosynthesis [[cite:PUB00151494]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | 4-amino-4-deoxychorismate lyase activity | Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H(+) + pyruvate. | ||
| Molecular function | Pyridoxal phosphate binding | Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. | ||
| Biological process | Folic acid biosynthetic process | The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: branched-chain-amino-acid aminotransferase-like protein 3, chloroplastic-like [Cicer arietinum] gi|502088132|ref|XP_004488745.1| | 9 | ||
| – | PREDICTED: branched-chain-amino-acid aminotransferase-like protein 3, chloroplastic-like [Cicer arietinum] gi|502088132|ref|XP_004488745.1| | 9 | ||
| – | Branched-chain-amino-acid aminotransferase-like protein; TAIR: AT5G57850.1 D-aminoacid aminotransferase-like PLP-dependent enzymes superfamily protein; Swiss-Prot: sp|Q8L493|DAAA_ARATH D-amino-acid transaminase, chloroplastic; TrEMBL-Plants: tr|I3SWY2|I3SWY2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0156200 | 12 | ||
| – | Branched-chain-amino-acid aminotransferase-like protein; TAIR: AT5G57850.1 D-aminoacid aminotransferase-like PLP-dependent enzymes superfamily protein; Swiss-Prot: sp|Q8L493|DAAA_ARATH D-amino-acid transaminase, chloroplastic; TrEMBL-Plants: tr|I3SWY2|I3SWY2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0156200 | 12 | ||
| – | Branched-chain-amino-acid aminotransferase-like protein; TAIR: AT5G57850.1 D-aminoacid aminotransferase-like PLP-dependent enzymes superfamily protein; Swiss-Prot: sp|Q8L493|DAAA_ARATH D-amino-acid transaminase, chloroplastic; TrEMBL-Plants: tr|I3SWY2|I3SWY2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0156200 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01559 | CDD | 1 | 20.00 |