Description

IPR018000 is a Neurotransmitter-gated ion-channel, conserved site.

<p>This entry represents a conserved site based around two highly conserved cysteines in the N-terminal of AchR/GABA/5HT3/Gly receptors. The residues between these two cysteines are also well conserved. In AchR, these cysteine residues have been shown to form a disulphide bond essential to the tertiary structure of the receptor.</p> <p>Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [[cite:PUB00002675], [cite:PUB00003455]]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily:</p> <ul> <li>Nicotinic acetylcholine receptor (AchR), an excitatory cation channel in vertebrates and invertebrates; in vertebrate motor endplates it is composed of alpha, beta, gamma and delta/epsilon subunits; in neurons it is composed of alpha and non-alpha (or beta) subunits [[cite:PUB00044612]].</li> <li>Glycine receptor, an inhibitory chloride ion channel composed of alpha and beta subunits [[cite:PUB00044613]].</li> <li>Gamma-aminobutyric acid (GABA) receptor, an inhibitory chloride ion channel; at least four types of subunits (alpha, beta, gamma and delta) are known [[cite:PUB00044614]].</li> <li>Serotonin 5HT3 receptor, of which there are seven major types (5HT3-5HT7) [[cite:PUB00010340]].</li> <li>Glutamate receptor, an excitatory cation channel of which at least three types have been described (kainate, N-methyl-D-aspartate (NMDA) and quisqualate) [[cite:PUB00044615]].</li> </ul> <p>These receptors possess a pentameric structure (made up of varying subunits), surrounding a central pore. All known sequences of subunits from neurotransmitter-gated ion-channels are structurally related. They are composed of a large extracellular glycosylated N-terminal ligand-binding domain, followed by three hydrophobic transmembrane regions which form the ionic channel, followed by an intracellular region of variable length. A fourth hydrophobic region is found at the C-terminal of the sequence [[cite:PUB00002675], [cite:PUB00003455]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 4

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: