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IPR018086 is a NADH:ubiquinone oxidoreductase, subunit 1, conserved site.
<p>NADH:ubiquinone oxidoreductase (complex I) ([ec:7.1.1.2]) is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) [[cite:PUB00005074]]. Complex I is a major source of reactive oxygen species (ROS) that are predominantly formed by electron transfer from FMNH(2). Complex I is found in bacteria, cyanobacteria (as a NADH-plastoquinone oxidoreductase), archaea [[cite:PUB00043561]], mitochondria, and in the hydrogenosome, a mitochondria-derived organelle. In general, the bacterial complex consists of 14 different subunits, while the mitochondrial complex contains homologues to these subunits in addition to approximately 31 additional proteins [[cite:PUB00045437]].</p> <p>This entry represents subunit 1 NADH:ubiquinone oxidoreductase [[cite:PUB00001392]]. Among the many polypeptide subunits that make up complex I, there are fifteen which are located in the membrane part, seven of which are encoded by the mitochondrial and chloroplast genomes of most species. The most conserved of these organelle-encoded subunits is known as subunit 1 (gene ND1 in mitochondrion, and NDH1 in chloroplast) and seems to contain the ubiquinone binding site.</p> <p>The ND1 subunit is highly similar to subunit 4 of Escherichia coli formate hydrogenlyase (gene hycD), subunit C of hydrogenase-4 (gene hyfC). Paracoccus denitrificans NQO8 and Escherichia coli nuoH NADH-ubiquinone oxidoreductase subunits also belong to this family [[cite:PUB00003309]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: NADH-ubiquinone oxidoreductase chain 1-like [Cicer arietinum] gi|502128802|ref|XP_004500085.1| | 9 | ||
| – | NADH-ubiquinone oxidoreductase chain [Medicago truncatula] gi|357436019|ref|XP_003588285.1| | 11 | ||
| – | NADH dehydrogenase subunit 1 [Lotus japonicus] gi|13518492|ref|NP_084850.1| | 14 | ||
| – | PREDICTED: NADH-ubiquinone oxidoreductase chain 1-like [Cicer arietinum] gi|502128802|ref|XP_004500085.1| | 9 | ||
| – | NADH-ubiquinone oxidoreductase chain 1; TAIR: ATMG01275.1 NADH dehydrogenase 1A (ChrM); Swiss-Prot: sp|Q01300|NU1M_PETHY NADH-ubiquinone oxidoreductase chain 1; TrEMBL-Plants: tr|R4IUS3|R4IUS3_VICFA NADH-ubiquinone oxidoreductase chain 1; Found in the gene: LotjaGi5g1v0123100 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 20.00 |