Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR018189 is a Phosphoglucose isomerase, conserved site.
<p>Phosphoglucose isomerase ([ec:5.3.1.9]) (PGI) [[cite:PUB00004511], [cite:PUB00003422]] is a dimeric enzyme that catalyses the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. PGI is involved in different pathways: in most higher organisms it is involved in glycolysis; in mammals it is involved in gluconeogenesis; in plants in carbohydrate biosynthesis; in some bacteria it provides a gateway for fructose into the Entner-Doudouroff pathway. The multifunctional protein, PGI, is also known as neuroleukin (a neurotrophic factor that mediates the differentiation of neurons), autocrine motility factor (a tumour-secreted cytokine that regulates cell motility), differentiation and maturation mediator and myofibril-bound serine proteinase inhibitor, and has different roles inside and outside the cell. In the cytoplasm, it catalyses the second step in glycolysis, while outside the cell it serves as a nerve growth factor and cytokine [[cite:PUB00006471]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Glucose-6-phosphate isomerase activity | Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. | ||
| Biological process | Gluconeogenesis | The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. | ||
| Biological process | Glycolytic process | The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: glucose-6-phosphate isomerase 1, chloroplastic-like isoform X1 [Cicer arietinum] gi|502095323|ref|XP_004490427.1| | 13 | ||
| – | Glucose-6-phosphate isomerase [Medicago truncatula] gi|357496261|ref|XP_003618419.1| | 15 | ||
| – | PREDICTED: glucose-6-phosphate isomerase-like [Glycine max] gi|356508007|ref|XP_003522754.1| | 13 | ||
| – | PREDICTED: glucose-6-phosphate isomerase, cytosolic 1-like [Glycine max] gi|356572070|ref|XP_003554193.1| | 11 | ||
| – | Glucose-6-phosphate isomerase [Medicago truncatula] gi|357496261|ref|XP_003618419.1| | 13 | ||
| – | Glucose-6-phosphate isomerase; TAIR: AT4G24620.1 phosphoglucose isomerase 1; Swiss-Prot: sp|Q8H103|G6PIP_ARATH Glucose-6-phosphate isomerase 1, chloroplastic; TrEMBL-Plants: tr|A0A0L9UZX3|A0A0L9UZX3_PHAAN Glucose-6-phosphate isomerase; Found in the gene: LotjaGi1g1v0138800 | 15 | ||
| – | Glucose-6-phosphate isomerase; TAIR: AT5G42740.1 Sugar isomerase (SIS) family protein; Swiss-Prot: sp|P54235|G6PI1_CLACO Glucose-6-phosphate isomerase, cytosolic 1; TrEMBL-Plants: tr|I1JTB8|I1JTB8_SOYBN Glucose-6-phosphate isomerase; Found in the gene: LotjaGi1g1v0274300 | 18 | ||
| – | Glucose-6-phosphate isomerase; TAIR: AT5G42740.1 Sugar isomerase (SIS) family protein; Swiss-Prot: sp|P54235|G6PI1_CLACO Glucose-6-phosphate isomerase, cytosolic 1; TrEMBL-Plants: tr|I1JTB8|I1JTB8_SOYBN Glucose-6-phosphate isomerase; Found in the gene: LotjaGi1g1v0274300 | 18 | ||
| – | Glucose-6-phosphate isomerase; TAIR: AT4G24620.1 phosphoglucose isomerase 1; Swiss-Prot: sp|Q8H103|G6PIP_ARATH Glucose-6-phosphate isomerase 1, chloroplastic; TrEMBL-Plants: tr|I1JV39|I1JV39_SOYBN Glucose-6-phosphate isomerase; Found in the gene: LotjaGi1g1v0348400 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd05016 | CDD | 1 | 11.11 |