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IPR035476 is a Phosphoglucose isomerase, SIS domain 1.
<p>Phosphoglucose isomerase (PGI) is a multifunctional enzyme which as an intracellular dimer catalyses the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate [[cite:PUB00004511]]. As an extracellular protein, PGI also has functions equivalent to neuroleukin (NLK), autocrine motility factor (AMF), and maturation factor (MF) [[cite:PUB00006445], [cite:PUB00011130]]. Evidence suggests that PGI, NLK, AMF, and MF are closely related or identical. NLK is a neurotrophic growth factor that promotes regeneration and survival of neurons. The dimeric form of NLK has isomerase function, whereas its monomeric form carries out neurotrophic activity. AMF is a cytokine that stimulates cell migration and metastasis. MF mediates the differentiation of human myeloid leukemic HL-60 cells to terminal monocytic cells.</p> <p>PGI is comprised of two domains; each domain is an α-β-α sandwich [[cite:PUB00021806]], which correspond to a SIS (Sugar ISomerase) domain fold.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Glucose-6-phosphate isomerase; TAIR: AT4G24620.1 phosphoglucose isomerase 1; Swiss-Prot: sp|Q8H103|G6PIP_ARATH Glucose-6-phosphate isomerase 1, chloroplastic; TrEMBL-Plants: tr|A0A0L9UZX3|A0A0L9UZX3_PHAAN Glucose-6-phosphate isomerase; Found in the gene: LotjaGi1g1v0138800 | 15 | ||
| – | Glucose-6-phosphate isomerase; TAIR: AT5G42740.1 Sugar isomerase (SIS) family protein; Swiss-Prot: sp|P54235|G6PI1_CLACO Glucose-6-phosphate isomerase, cytosolic 1; TrEMBL-Plants: tr|I1JTB8|I1JTB8_SOYBN Glucose-6-phosphate isomerase; Found in the gene: LotjaGi1g1v0274300 | 18 | ||
| – | Glucose-6-phosphate isomerase; TAIR: AT5G42740.1 Sugar isomerase (SIS) family protein; Swiss-Prot: sp|P54235|G6PI1_CLACO Glucose-6-phosphate isomerase, cytosolic 1; TrEMBL-Plants: tr|I1JTB8|I1JTB8_SOYBN Glucose-6-phosphate isomerase; Found in the gene: LotjaGi1g1v0274300 | 18 | ||
| – | Glucose-6-phosphate isomerase; TAIR: AT4G24620.1 phosphoglucose isomerase 1; Swiss-Prot: sp|Q8H103|G6PIP_ARATH Glucose-6-phosphate isomerase 1, chloroplastic; TrEMBL-Plants: tr|I1JV39|I1JV39_SOYBN Glucose-6-phosphate isomerase; Found in the gene: LotjaGi1g1v0348400 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd05016 | CDD | 1 | 25.00 |