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IPR018791 is a UV radiation resistance protein/autophagy-related protein 14.
<p>This entry includes Atg14 (autophagy-related protein 14) from budding yeasts and their homologues, Atg14L/Bakor (beclin-1-associated autophagy-related key regulator) and UVRAG (UV irradiation resistance-associated gene), from animals.</p> <p>Atg14 is a hydrophilic protein with a coiled-coil motif at the N terminus region. Yeast cells with mutant Atg14 are defective not only in autophagy but also in sorting of carboxypeptidase Y (CPY), a vacuolar-soluble hydrolase, to the vacuole [[cite:PUB00009843]].</p> <p>Barkor positively regulates autophagy through its interaction with Beclin-1, with decreased levels of autophagosome formation observed when Barkor expression is eliminated [[cite:PUB00054155]]. UVRAG is also a Beclin-1 binding protein that positively stimulate starvation-induced autophagy [[cite:PUB00084155]]. Autophagy mediates the cellular response to nutrient deprivation, protein aggregation, and pathogen invasion in humans, and malfunction of autophagy has been implicated in multiple human diseases including cancer.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | DNA-directed RNA polymerase II protein isoform 1 [Theobroma cacao] gi|508724223|gb|EOY16120.1| | 5 | ||
| – | DNA-directed RNA polymerase II protein isoform 1 [Theobroma cacao] gi|508724223|gb|EOY16120.1| | 6 | ||
| – | DNA-directed RNA polymerase II; TAIR: AT4G08540.1 DNA-directed RNA polymerase II protein; Swiss-Prot: sp|Q1QUR7|MNMA_CHRSD tRNA-specific 2-thiouridylase MnmA; TrEMBL-Plants: tr|I1MAP2|I1MAP2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0150300 | 6 | ||
| – | DNA-directed RNA polymerase II; TAIR: AT4G08540.1 DNA-directed RNA polymerase II protein; Swiss-Prot: sp|Q1QUR7|MNMA_CHRSD tRNA-specific 2-thiouridylase MnmA; TrEMBL-Plants: tr|I1MAP2|I1MAP2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0150300 | 6 | ||
| – | DNA-directed RNA polymerase II; TAIR: AT4G08540.1 DNA-directed RNA polymerase II protein; Swiss-Prot: sp|Q09315|5NT3_CAEEL Putative cytosolic 5'-nucleotidase 3; TrEMBL-Plants: tr|A0A0R0GEA1|A0A0R0GEA1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0150300 | 6 | ||
| – | DNA-directed RNA polymerase II; TAIR: AT4G08540.1 DNA-directed RNA polymerase II protein; Swiss-Prot: sp|Q1QUR7|MNMA_CHRSD tRNA-specific 2-thiouridylase MnmA; TrEMBL-Plants: tr|I1MAP2|I1MAP2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0150300 | 6 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 16.67 |