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IPR019163 is a THO complex, subunit 5.
<p>This entry represents Thoc5 which is one of the subunits of the THO complex, which additionally contains: HPR1, Thoc2, Thoc6 and Thoc7. The evolutionarily conserved multisubunit THO complex, which is recruited to actively transcribed genes is required for the efficient expression of genes that have internal tandem repeats. It is suggested that the THO complex functions to rectify aberrant structures that arise during transcription [[cite:PUB00045308], [cite:PUB00045309]] and is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress [[cite:PUB00044694]].</p> <p>This entry also identifies the crucial 144 N-terminal residues of the FMIP protein, which is essential for the binding of the protein to the cytoplasmic domain of activated Fms-molecules in M-CSF induced haematopoietic differentiation of macrophages. The C terminus contains a putative nuclear localisation sequence and a leucine zipper which suggest further, as yet unknown, nuclear functions. The level of FMIP expression might form a threshold that determines whether cells differentiate into macrophages or into granulocytes [[cite:PUB00044982]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: THO complex subunit 5 homolog [Cicer arietinum] gi|502132856|ref|XP_004501561.1| | 6 | ||
| – | THO complex subunit 5 like; TAIR: AT5G42920.2 THO complex, subunit 5; Swiss-Prot: sp|F4K4J0|THO5B_ARATH THO complex subunit 5B; TrEMBL-Plants: tr|A0A151TDI2|A0A151TDI2_CAJCA THO complex subunit 5 isogeny; Found in the gene: LotjaGi1g1v0355500 | 5 | ||
| – | THO complex subunit 5 like; TAIR: AT5G42920.2 THO complex, subunit 5; Swiss-Prot: sp|F4K4J0|THO5B_ARATH THO complex subunit 5B; TrEMBL-Plants: tr|D5LMF8|D5LMF8_9FABA Cold-induce protein; Found in the gene: LotjaGi1g1v0355500 | 5 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |