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IPR019400 is a Peptidase C65, otubain.
<p>This family of proteins is a highly specific ubiquitin iso-peptidase that removes ubiquitin from proteins [[cite:PUB00045069]]. The modification of cellular proteins by ubiquitin (Ub) is an important event that underlies protein stability and function in eukaryotes, as it is a dynamic and reversible process. Otubain carries several key conserved domains: (i) the OTU (ovarian tumour domain) in which there is an active cysteine protease triad (ii) a nuclear localisation signal, (iii) a Ub interaction motif (UIM)-like motif phi-xx-A-xxxs-xx-Ac (where phi indicates an aromatic amino acid, x indicates any amino acid and Ac indicates an acidic amino acid), (iv) a Ub-associated (UBA)-like domain and (v) the LxxLL motif [[cite:PUB00063614]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: ubiquitin thioesterase otubain-like [Glycine max] gi|356554953|ref|XP_003545805.1| | 8 | ||
| – | PREDICTED: ubiquitin thioesterase otubain-like [Glycine max] gi|356554953|ref|XP_003545805.1| | 7 | ||
| – | Ubiquitin thioesterase; TAIR: AT1G28120.1 ubiquitin thioesterase otubain-like protein; Swiss-Prot: sp|Q8LG98|OTUBL_ARATH Ubiquitin thioesterase otubain-like; TrEMBL-Plants: tr|I1ME83|I1ME83_SOYBN Ubiquitin thioesterase; Found in the gene: LotjaGi6g1v0342100 | 15 | ||
| – | Ubiquitin thioesterase; TAIR: AT1G28120.1 ubiquitin thioesterase otubain-like protein; Swiss-Prot: sp|Q8LG98|OTUBL_ARATH Ubiquitin thioesterase otubain-like; TrEMBL-Plants: tr|A0A0B2RN98|A0A0B2RN98_GLYSO Ubiquitin thioesterase; Found in the gene: LotjaGi6g1v0342100 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF54001 | SUPERFAMILY | 1 | 25.00 |