Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR019465 is a Conserved oligomeric Golgi complex subunit 5.
<p>The COG complex, the peripheral membrane oligomeric protein complex involved in intra-Golgi protein trafficking, consists of eight subunits arranged in two lobes bridged by Cog1. Cog5 is in the smaller, B lobe, bound in with Cog6-8, and is itself bound to Cog1 as well as, strongly, to Cog7 [[cite:PUB00044937], [cite:PUB00100042]].</p> <p>Defects in COG5 are the cause of congenital disorder of glycosylation type 2I (CDG2I). A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterised by under-glycosylated serum glycoproteins [[cite:PUB00062957]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Intra-Golgi vesicle-mediated transport | The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network). | ||
| Cellular component | Golgi transport complex | A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p). In mammals the subunits are named COG1-8. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: conserved oligomeric Golgi complex subunit 5-like [Glycine max] gi|356501473|ref|XP_003519549.1| | 6 | ||
| – | Conserved oligomeric Golgi complex subunit [Medicago truncatula] gi|357494245|ref|XP_003617411.1| | 4 | ||
| – | PREDICTED: conserved oligomeric Golgi complex subunit 5-like [Cicer arietinum] gi|502098814|ref|XP_004491323.1| | 3 | ||
| – | Conserved oligomeric Golgi complex subunit 5; TAIR: AT1G67930.1 Golgi transport complex protein-like protein; Swiss-Prot: sp|Q9UP83|COG5_HUMAN Conserved oligomeric Golgi complex subunit 5; TrEMBL-Plants: tr|I1JJ41|I1JJ41_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0043000 | 5 | ||
| – | Conserved oligomeric Golgi complex subunit 5; TAIR: AT1G67930.1 Golgi transport complex protein-like protein; Swiss-Prot: sp|Q9UP83|COG5_HUMAN Conserved oligomeric Golgi complex subunit 5; TrEMBL-Plants: tr|I1JJ41|I1JJ41_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0043000 | 6 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd05681 | CDD | 1 | 20.00 |