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IPR019479 is a Peroxiredoxin, C-terminal.
<p>This entry represents the C-terminal domain of 1-Cys peroxiredoxin, a member of the peroxiredoxin superfamily which protect cells against membrane oxidation through glutathione (GSH)-dependent reduction of phospholipid hydroperoxides to corresponding alcohols [[cite:PUB00022453]]. The C-terminal domain is crucial for providing the extra cysteine necessary for dimerisation of the whole molecule. Loss of the enzyme's peroxidase activity is associated with oxidation of the catalytic cysteine found upstream of this domain. Glutathionylation, presumably through its disruption of protein structure, facilitates access for GSH, resulting in spontaneous reduction of the mixed disulphide to the sulphydryl and consequent activation of the enzyme [[cite:PUB00044127]]. The domain is associated with [interpro:IPR000866], which carries the catalytic cysteine.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Peroxiredoxin activity | Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: LOW QUALITY PROTEIN: 1-Cys peroxiredoxin-like [Glycine max] gi|356512223|ref|XP_003524820.1| | 16 | ||
| – | PREDICTED: 2-Cys peroxiredoxin BAS1-like, chloroplastic-like [Glycine max] gi|356500615|ref|XP_003519127.1| | 15 | ||
| – | Peroxiredoxin; TAIR: AT5G06290.1 2-cysteine peroxiredoxin B; Swiss-Prot: sp|Q9C5R8|BAS1B_ARATH 2-Cys peroxiredoxin BAS1-like, chloroplastic; TrEMBL-Plants: tr|A0A1J7IHB4|A0A1J7IHB4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0735500 | 13 | ||
| – | Peroxiredoxin, putative; TAIR: AT1G48130.1 1-cysteine peroxiredoxin 1; Swiss-Prot: sp|Q6E2Z6|REHY_MEDTR 1-Cys peroxiredoxin; TrEMBL-Plants: tr|I3SM62|I3SM62_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0020000 | 15 | ||
| – | Peroxiredoxin; TAIR: AT5G06290.1 2-cysteine peroxiredoxin B; Swiss-Prot: sp|Q9C5R8|BAS1B_ARATH 2-Cys peroxiredoxin BAS1-like, chloroplastic; TrEMBL-Plants: tr|I3SQA4|I3SQA4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0102700 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |