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IPR019842

Source: InterPro

Description

IPR019842 is a Uricase, conserved site.

<p>Uricase ([ec:1.7.3.3]) (urate oxidase) [[cite:PUB00002471]] is the peroxisomal enzyme responsible for the degradation of urate into allantoin:</p> <p><reaction> Urate + O<sub>2</sub> + H<sub>2</sub>O = 5-hydroxyisourate + H<sub>2</sub>O<sub>2</sub> </reaction></p> <p>Some species, like primates and birds, have lost the gene for uricase and are therefore unable to degrade urate [[cite:PUB00004693]]. Uricase is a protein of 300 to 400 amino acids, its sequence is well conserved. It is mainly localised in the liver, where it forms a large electron-dense paracrystalline core in many peroxisomes [[cite:PUB00001587]]. The enzyme exists as a tetramer of identical subunits, each containing a possible type 2 copper-binding site [[cite:PUB00004693]]. In legumes, 2 forms of uricase are found: in the roots, the tetrameric form; and, in the uninfected cells of root nodules, a monomeric form, which plays an important role in nitrogen-fixation [[cite:PUB00004611]].</p> <p>The signature pattern used to create this entry covers a highly conserved region located in the central part of the sequence.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004846
Molecular function Urate oxidase activity Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + hydrogen peroxide.
Subterm of
GO:0006144
Biological process Purine nucleobase metabolic process The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
Subterm of
GO:0055114
Biological process Oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi6g1v0015500.1
– Uricase; TAIR: AT2G26230.1 uricase / urate oxidase / nodulin 35; Swiss-Prot: sp|P34798|URIC1_CANLI Uricase-2 isozyme 1; TrEMBL-Plants: tr|Q9FRY6|Q9FRY6_LOTJA Uricase; Found in the gene: LotjaGi6g1v0015500
Domains
12

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd00445 CDD 1 100.00