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IPR021196

Description

IPR021196 is a PdxT/SNO family, conserved site.

<p>The term vitamin B6 is used to refer collectively to the compound pyridoxine and its vitameric forms, pyridoxal, pyridoxamine, and their phosphorylated derivatives. Vitamin B6 is required by all organisms and plays an essential role as a co-factor for enzymatic reactions. Plants, fungi, bacteria, archaebacteria, and protists synthetize vitamin B6. Animals and some highly specialised obligate pathogens obtain it nutritionally. Vitamin B6 has two distinct biosynthetic pathways, which do not coexist in any organism. The pdxA/pdxJ pathway, that has been extensively characterised in Escherichia coli, is found in the gamma subdivision of the proteobacteria. A second pathway of vitamin B6 synthesis involving the pdxS/SNZ and pdxT/SNO protein families, which are completely unrelated in sequence to the pdxA/pdxJ proteins, is found in plants, fungi, protists, archaebacteria, and most bacteria.</p> <p>PdxS/SNZ and pdxT/SNO proteins form a complex which serves as a glutamine amidotransferase to supply ammonia as a source of the ring nitrogen of vitamin B6 [[cite:PUB00018041]]. PdxT/SNO and pdxS/SNZ appear to encode respectively the glutaminase subunit, which produces ammonia from glutamine, and the synthase subunit, which combines ammonia with five- and three-carbon phosphosugars to form vitamin B6 [[cite:PUB00018042]].</p> <p>The pdxT/SNO family belongs to the triad glutamine aminotransferase fold, characterised by a conserved Cys-His-Glu active site [[cite:PUB00018044]]. Two regions are highly conserved across all taxa, the PGGEST motif and the FHPE(LT) motif [[cite:PUB00018045]]. PdxT/SNO proteins are an α/β three-layer sandwich containing a seven- stranded twisted mixed parallel β-sheet flanked by a six α-helices on the N-terminal stretch of the sheet, four on one side and two on the other [[cite:PUB00018044]].</p> <p>Proteins belonging to the pdxT/SNO family include:</p> <ul> <li>Bacillus subtilis glutamine amidotransferase subunit pdxT</li> <li>Haemophilus influenzae glutamine amidotransferase subunit pdxT</li> <li>Methanococcus jannaschii glutamine amidotransferase subunit pdxT</li> <li>Yeast probable glutamine amidotransferase SNO1</li> <li>Yeast probable glutamine amidotransferase SNO2</li> <li>Yeast probable glutamine amidotransferase SNO3</li> </ul> <p>These are hydrophilic proteins of about 19 to 25 Kd.</p> <p>This entry represents a conserved site containing the PGGEST motif.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
PREDICTED: pyridoxal biosynthesis protein PDX2-like [Cicer arietinum] gi|502147413|ref|XP_004506773.1| 14
Pyridoxal 5'-phosphate synthase subunit PdxT; TAIR: AT5G60540.1 pyridoxine biosynthesis 2; Swiss-Prot: sp|Q8LAD0|PDX2_ARATH Probable pyridoxal 5'-phosphate synthase subunit PDX2; TrEMBL-Plants: tr|I3SUR2|I3SUR2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0210000 14
Pyridoxal 5'-phosphate synthase subunit PdxT; TAIR: AT5G60540.1 pyridoxine biosynthesis 2; Swiss-Prot: sp|Q8LAD0|PDX2_ARATH Probable pyridoxal 5'-phosphate synthase subunit PDX2; TrEMBL-Plants: tr|I3SUR2|I3SUR2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0210000 14

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd01749 CDD 1 33.33