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IPR021668

Source: InterPro

Description

IPR021668 is a Telomere-length maintenance and DNA damage repair.

<p>ATM is a large protein kinase, in humans, critical for responding to DNA double-strand breaks (DSBs). Tel1, the orthologue from budding yeast, also regulates responses to DSBs. Tel1 is important for maintaining viability and for phosphorylation of the DNA damage signal transducer kinase Rad53 (an orthologue of mammalian CHK2). In addition to functioning in the response to DSBs, numerous findings indicate that Tel1/ATM regulates telomeres. The overall domain structure of Tel1/ATM is shared by proteins of the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family, but this family carries a unique and functionally important TAN sequence motif, near its N-terminal, LxxxKxxE/DRxxxL. which is conserved specifically in the Tel1/ATM subclass of the PIKKs. The TAN motif is essential for both telomere length maintenance and Tel1 action in response to DNA damage [[cite:PUB00053531]]. It is classified as an [ec:2.7.11.1].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004674
Molecular function Protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
Subterm of

Associated Lotus transcripts 4

Transcript Name Description Predicted domains Domain count
Lj0g3v0293169.1
– Serine/threonine protein kinase ATM [Medicago truncatula] gi|357461959|ref|XP_003601261.1|
Domains
4
Lj0g3v0293169.2
– Serine/threonine protein kinase ATM [Medicago truncatula] gi|357461959|ref|XP_003601261.1|
Domains
4
Lj0g3v0293169.3
– Serine/threonine protein kinase ATM [Medicago truncatula] gi|357461959|ref|XP_003601261.1|
Domains
8
LotjaGi1g1v0180100.1
– Serine/threonine-protein kinase ATM; TAIR: AT3G48190.2 Serine/Threonine-kinase ATM-like protein; Swiss-Prot: sp|Q9M3G7|ATM_ARATH Serine/threonine-protein kinase ATM; TrEMBL-Plants: tr|A0A0R0KEL0|A0A0R0KEL0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0180100
Domains
7

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 25.00