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IPR038980

Source: InterPro

Description

IPR038980 is a Serine/threonine-protein kinase ATM, plant.

<p>ATM acts as a DNA damage sensor upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA) [[cite:PUB00062189], [cite:PUB00062194]]. It regulate DNA damage response mechanism through recognising the substrate consensus sequence [ST]-Q and phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs) [[cite:PUB00062186]]. On DNA damage, autophosphorylation dissociates ATM into monomers rendering them catalytically active [[cite:PUB00062192], [cite:PUB00062193]]. It can phosphorylate DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C [[cite:PUB00062195], [cite:PUB00062196], [cite:PUB00062197], [cite:PUB00062198], [cite:PUB00062199]]. ATM is also required for telomere elongation [[cite:PUB00088376]]. ATM also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes [[cite:PUB00062187]]. It is also involved in signal transduction and cell cycle control and may function as a tumour suppressor [[cite:PUB00062190]].</p> <p>This entry includes ATM (Ataxia Telangiectasia Mutated) from plants, including AtATM from Arabidopsis and its homologues from fungi. AtATM is an Arabidopsis homologue of the human ATM gene and plays a important role in the response to both stress-induced and developmentally programmed DNA damage [[cite:PUB00088628], [cite:PUB00088627]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004674
Molecular function Protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
Subterm of
GO:0006974
Biological process Cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0180100.1
– Serine/threonine-protein kinase ATM; TAIR: AT3G48190.2 Serine/Threonine-kinase ATM-like protein; Swiss-Prot: sp|Q9M3G7|ATM_ARATH Serine/threonine-protein kinase ATM; TrEMBL-Plants: tr|A0A0R0KEL0|A0A0R0KEL0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0180100
Domains
7

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 100.00