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IPR021935 is a Small G protein signalling modulator 1/2, Rab-binding domain.
<p>This domain adopts a PH-like fold. It has been called the Rab-binding domain (RBD) [[cite:PUB00087562]].</p> <p>Small G-protein signalling modulator 1/2 (also known as RUTBC2/1) bind to Rab9A via their Pleckstrin homology (PH) domain [[cite:PUB00087560], [cite:PUB00087561]]. RUTBC1 stimulates GTP hydrolysis by Rab32 and Rab33B [[cite:PUB00087561]], while RUTBC2 appears to be a GAP for Rab36, Rab9A and associated proteins controling the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi [[cite:PUB00087562], [cite:PUB00087560], [cite:PUB00086312]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | TBC1 domain family member [Medicago truncatula] gi|357478201|ref|XP_003609386.1| | 11 | ||
| – | RabGAP/TBC domain protein; TAIR: AT5G52580.1 RabGAP/TBC domain-containing protein; Swiss-Prot: sp|Q8TC07|TBC15_HUMAN TBC1 domain family member 15; TrEMBL-Plants: tr|G7JE75|G7JE75_MEDTR RabGAP/TBC domain protein; Found in the gene: LotjaGi4g1v0274400 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |