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IPR022577 is a Tubulin-folding cofactor D, C-terminal domain.
<p>This region is found in TBCD and its paralogues in eukaryotes. It is typically between 182 and 199 amino acids in length. There is a single completely conserved residue R that may be functionally important.</p> <p>Tubulin-folding cofactor D (TBCD) can interact with beta tubulin, which is regulated via its interaction with ARL2 (ADP ribosylation factor-like protein 2), a small monomeric G protein. ARL2 inhibits the beta-tubulin GTPase activating protein (GAP) activity of TBCD, and its interaction with native tubulin dimers [[cite:PUB00010143], [cite:PUB00077911]]. TBCD does not co-polymerise with microtubules either in vivo or in vitro, but instead modulates microtubule dynamics by sequestering beta-tubulin from GTP-bound alpha/beta-heterodimers in microtubules [[cite:PUB00053749]].</p> <p>The tubulin heterodimer consists of one alpha- and one beta-tubulin polypeptide. In humans, five tubulin-specific chaperones termed TBCA/B/C/D/E are essential for bring the alpha- and beta-tubulin subunits together into a tightly associated heterodimer. Following the generation of quasi-native beta- and alpha-tubulin polypeptides (via multiple rounds of ATP-dependent interaction with the cytosolic chaperonin), TBCA and TBCB bind to and stabilise newly synthesised beta- and alpha-tubulin, respectively. The exchange of beta-tubulin between TBCA and TBCD, and of alpha-tubulin between TBCB and TBCE, resulting in the formation of TBCD/beta and TBCE/alpha. These two complexes then interact with each other and form a supercomplex (TBCE/alpha/TBCD/beta). Interaction of the supercomplex with TBCC causes the disassembly of the supercomplex and the release of E-site GDP-bound alpha/beta tubulin heterodimer, which becomes polymerization competent following spontaneous exchange with GTP [[cite:PUB00077898]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: tubulin-specific chaperone D-like [Glycine max] gi|356534400|ref|XP_003535743.1| | 10 | ||
| – | PREDICTED: tubulin-specific chaperone D-like [Glycine max] gi|356534400|ref|XP_003535743.1| | 12 | ||
| – | PREDICTED: tubulin-specific chaperone D-like [Glycine max] gi|356574161|ref|XP_003555220.1| | 10 | ||
| – | Tubulin-folding cofactor d; TAIR: AT3G60740.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q8L5R3|TBCD_ARATH Tubulin-folding cofactor D; TrEMBL-Plants: tr|A0A0B2PUP1|A0A0B2PUP1_GLYSO Tubulin-specific chaperone D; Found in the gene: LotjaGi5g1v0344800 | 11 | ||
| – | Tubulin-folding cofactor d; TAIR: AT3G60740.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q8L5R3|TBCD_ARATH Tubulin-folding cofactor D; TrEMBL-Plants: tr|A0A0B2PUP1|A0A0B2PUP1_GLYSO Tubulin-specific chaperone D; Found in the gene: LotjaGi5g1v0344800 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |