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IPR022800 is a Spt4/RpoE2 zinc finger.
<p>This entry consists of several eukaryotic transcription elongation Spt4 proteins as well as archaebacterial RpoE2 [[cite:PUB00010582]]. Three transcription-elongation factors Spt4, Spt5, and Spt6 are conserved among eukaryotes and are essential for transcription via the modulation of chromatin structure. Spt4 and Spt5 are tightly associated in a complex, while the physical association of the Spt4-Spt5 complex with Spt6 is considerably weaker. It has been demonstrated that Spt4, Spt5, and Spt6 play roles in transcription elongation in both yeast and humans including a role in activation by Tat. It is known that Spt4, Spt5, and Spt6 are general transcription-elongation factors, controlling transcription both positively and negatively in important regulatory and developmental roles [[cite:PUB00012261]]. RpoE2 is one of 13 subunits in the archaeal RNA polymerase. These proteins contain a C4-type zinc finger, and the structure has been solved in [[cite:PUB00053827]]. The structure reveals that Spt4-Spt5 binding is governed by an acid-dipole interaction between Spt5 and Spt4, and the complex binds to and travels along the elongating RNA polymerase. The Spt4-Spt5 complex is likely to be an ancient, core component of the transcription elongation machinery.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: transcription elongation factor SPT4 homolog 1-like [Glycine max] gi|356522132|ref|XP_003529703.1| | 11 | ||
| – | Transcription elongation factor SPT4 homolog; TAIR: AT5G08565.1 Transcription initiation Spt4-like protein; Swiss-Prot: sp|Q8LCQ3|SPT41_ARATH Transcription elongation factor SPT4 homolog 1; TrEMBL-Plants: tr|I3SN22|I3SN22_LOTJA Transcription elongation factor SPT4 homolog; Found in the gene: LotjaGi6g1v0274900 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd07973 | CDD | 1 | 50.00 |