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IPR022816 is a Condensin complex subunit 2/barren.
<p>This entry represents eukaryotic condensin complex subunit 2 proteins. Included in this group are several Barren protein homologues from several eukaryotic organisms. In Drosophila Barren (barr) is required for sister-chromatid segregation in mitosis. barr encodes a novel protein that is present in proliferating cells and has homologues in yeast and human. Mitotic defects in barr embryos become apparent during cycle 16, resulting in a loss of PNS and CNS neurons. Centromeres move apart at the metaphase-anaphase transition and Cyclin B is degraded, but sister chromatids remain connected, resulting in chromatin bridging. Barren protein localises to chromatin throughout mitosis. Colocalisation and biochemical experiments indicate that Barren associates with Topoisomerase II throughout mitosis and alters the activity of Topoisomerase II. It has been suggested that this association is required for proper chromosomal segregation by facilitating the decatenation of chromatids at anaphase [[cite:PUB00011266]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Condensin complex | A multisubunit protein complex that plays a central role in chromosome condensation. | ||
| Biological process | Mitotic chromosome condensation | The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: condensin complex subunit 2-like [Glycine max] gi|356544788|ref|XP_003540829.1| | 4 | ||
| – | Condensin complex subunit [Medicago truncatula] gi|357453327|ref|XP_003596940.1| | 4 | ||
| – | PREDICTED: condensin complex subunit 2-like [Glycine max] gi|356544788|ref|XP_003540829.1| | 4 | ||
| – | Condensin complex subunit 2; TAIR: AT2G32590.1 condensin complex subunit; Swiss-Prot: sp|Q564K3|CND2_ARATH Condensin complex subunit 2; TrEMBL-Plants: tr|A0A151RM81|A0A151RM81_CAJCA Condensin complex subunit 2; Found in the gene: LotjaGi3g1v0185400 | 6 | ||
| – | Condensin complex subunit 2; TAIR: AT2G32590.1 condensin complex subunit; Swiss-Prot: sp|Q564K3|CND2_ARATH Condensin complex subunit 2; TrEMBL-Plants: tr|A0A072UIX9|A0A072UIX9_MEDTR Condensin complex subunit 2; Found in the gene: LotjaGi3g1v0469400 | 6 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |