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IPR023005 is a Nucleoside diphosphate kinase, active site.
<p>Nucleoside diphosphate kinases ([ec:2.7.4.6]) (NDK) are enzymes required for the synthesis of nucleoside triphosphates (NTP) other than ATP. They provide NTPs for nucleic acid synthesis, CTP for lipid synthesis, UTP for polysaccharide synthesis and GTP for protein elongation, signal transduction and microtubule polymerisation. In eukaryotes, there seems to be a small family of NDK isozymes each of which acts in a different subcellular compartment and/or has a distinct biological function. Eukaryotic NDK isozymes are hexamers of two highly related chains (A and B) [[cite:PUB00002696]]. By random association (A6, A5B...AB5, B6), these two kinds of chain form isoenzymes differing in their isoelectric point. NDK are proteins of 17 Kd that act via a ping-pong mechanism in which a histidine residue is phosphorylated, by transfer of the terminal phosphate group from ATP. In the presence of magnesium, the phosphoenzyme can transfer its phosphate group to any NDP, to produce an NTP. NDK isozymes have been sequenced from prokaryotic and eukaryotic sources. It has also been shown [[cite:PUB00000847]] that the Drosophila awd (abnormal wing discs) protein, is a microtubule-associated NDK. Mammalian NDK is also known as metastasis inhibition factor nm23.</p> <p>The sequence of NDK has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism [[cite:PUB00002696]]. The signature pattern of this entry covers the active site histidine.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | RecName: Full=Nucleoside diphosphate kinase 4, chloroplastic; AltName: Full=Nucleoside diphosphate kinase III; AltName: Full=Nucleoside diphosphate kinase IV; Short=NDK IV; Short=NDP kinase IV; Short=NDPK IV; Flags: Precursorgi|19699051|gb|AAL91136.1| nucleoside diphosphate kinase III [Spinacia oleracea] gi|45477151|sp|Q8RXA8.1|NDK4_SPIOL | 10 | ||
| – | RecName: Full=Nucleoside diphosphate kinase 4, chloroplastic; AltName: Full=Nucleoside diphosphate kinase III; AltName: Full=Nucleoside diphosphate kinase IV; Short=NDK IV; Short=NDP kinase IV; Short=NDPK IV; Flags: Precursorgi|19699051|gb|AAL91136.1| nucleoside diphosphate kinase III [Spinacia oleracea] gi|45477151|sp|Q8RXA8.1|NDK4_SPIOL | 10 | ||
| – | Nucleoside diphosphate kinase IV [Arabidopsis thaliana] gi|18416233|ref|NP_567690.1| | 11 | ||
| – | PREDICTED: nucleoside diphosphate kinase 6-like isoform X3 [Cicer arietinum] gi|502156524|ref|XP_004510517.1| | 17 | ||
| – | PREDICTED: nucleoside diphosphate kinase 6-like isoform X5 [Cicer arietinum] gi|502156528|ref|XP_004510519.1| | 16 | ||
| – | PREDICTED: nucleoside diphosphate kinase 2, chloroplastic [Glycine max] gi|356513927|ref|XP_003525659.1| | 19 | ||
| – | RecName: Full=Nucleoside diphosphate kinase 4, chloroplastic; AltName: Full=Nucleoside diphosphate kinase III; AltName: Full=Nucleoside diphosphate kinase IV; Short=NDK IV; Short=NDP kinase IV; Short=NDPK IV; Flags: Precursorgi|19699051|gb|AAL91136.1| nucleoside diphosphate kinase III [Spinacia oleracea] gi|45477151|sp|Q8RXA8.1|NDK4_SPIOL | 18 | ||
| – | Nucleoside diphosphate kinase; TAIR: AT4G23900.1 Nucleoside diphosphate kinase family protein; Swiss-Prot: sp|Q8LAH8|NDK4_ARATH Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial; TrEMBL-Plants: tr|V4TLN6|V4TLN6_9ROSI Nucleoside diphosphate kinase; Found in the gene: LotjaGi2g1v0441200 | 14 | ||
| – | Nucleoside diphosphate kinase; TAIR: AT4G09320.1 nucleoside diphosphate kinase; Swiss-Prot: sp|Q39839|NDK1_SOYBN Nucleoside diphosphate kinase 1; TrEMBL-Plants: tr|I3S3D3|I3S3D3_LOTJA Nucleoside diphosphate kinase; Found in the gene: LotjaGi3g1v0068500 | 14 | ||
| – | Nucleoside diphosphate kinase; TAIR: AT1G17410.1 Nucleoside diphosphate kinase family protein; Swiss-Prot: sp|Q6NLG3|NDK5_ARATH Probable nucleoside diphosphate kinase 5; TrEMBL-Plants: tr|I3SBN5|I3SBN5_LOTJA Nucleoside diphosphate kinase; Found in the gene: LotjaGi3g1v0412500 | 19 | ||
| – | Nucleoside diphosphate kinase; TAIR: AT1G17410.1 Nucleoside diphosphate kinase family protein; Swiss-Prot: sp|Q6NLG3|NDK5_ARATH Probable nucleoside diphosphate kinase 5; TrEMBL-Plants: tr|I3SBN5|I3SBN5_LOTJA Nucleoside diphosphate kinase; Found in the gene: LotjaGi3g1v0412500 | 19 | ||
| – | Nucleoside diphosphate kinase; TAIR: AT5G63310.1 nucleoside diphosphate kinase 2; Swiss-Prot: sp|P47923|NDK2_PEA Nucleoside diphosphate kinase 2, chloroplastic; TrEMBL-Plants: tr|I3SNP5|I3SNP5_LOTJA Nucleoside diphosphate kinase; Found in the gene: LotjaGi4g1v0224100 | 21 | ||
| – | Nucleoside diphosphate kinase; TAIR: AT4G23895.3 Pleckstrin homology (PH) domain-containing protein; Swiss-Prot: sp|Q8RXA8|NDK4_SPIOL Nucleoside diphosphate kinase 4, chloroplastic; TrEMBL-Plants: tr|I3SS10|I3SS10_LOTJA Nucleoside diphosphate kinase; Found in the gene: LotjaGi4g1v0435100 | 20 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd04413 | CDD | 1 | 7.69 |