Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR024015 is a Pyridoxamine 5'-phosphate oxidase, probable FMN-dependent, Alr4036-like.
<p>Pyridoxamine 5'-phosphate oxidase ([ec:1.4.3.5]) is an enzyme that is involved in the de novo synthesis of pyridoxine (vitamin B6) and pyridoxal phosphate. It oxidizes pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P. The enzyme requires the presence of flavin mononucleotide (FMN) as a cofactor, although there is some evidence that coenzyme F420 may perform this role in some species [[cite:PUB00055044]].</p> <p>The sequences of the enzyme from bacterial (genes pdxH or fprA) [[cite:PUB00002199]] and fungal (gene PDX3) [[cite:PUB00002264]] sources show that this protein has been highly conserved throughout evolution. PdxH is evolutionary related [[cite:PUB00001735]] to one of the enzymes in the phenazine biosynthesis protein pathway, phzD (also known as phzG) [[cite:PUB00155385]].</p> <p>This entry represents a subfamily that is widespread in Cyanobacteria and plants, and is named for alr4036 from Nostoc sp. PCC 7120 ([swissprot:Q8YQ04]). The family consists mostly of proteins from species that lack the capability to synthesise F420, so it is probable that all members bind FMN rather than F420.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: pyridoxine/pyridoxamine 5'-phosphate oxidase 2-like isoform X1 [Cicer arietinum] gi|502156801|ref|XP_004510653.1| | 9 | ||
| – | Pyridoxine/pyridoxamine 5'-phosphate oxidase; TAIR: AT2G46580.1 Pyridoxamine 5'-phosphate oxidase family protein; Swiss-Prot: sp|Q9ZPY1|PPOX2_ARATH Pyridoxine/pyridoxamine 5'-phosphate oxidase 2; TrEMBL-Plants: tr|A0A072TP40|A0A072TP40_MEDTR Pyridoxamine 5'-phosphate oxidase family protein; Found in the gene: LotjaGi3g1v0398100 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR04026 | TIGRFAM | 1 | 50.00 |