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IPR024711 is a Catalase, mono-functional, haem-containing, clades 1 and 3.
<p>Catalases ([ec:1.11.1.6]) are antioxidant enzymes that catalyse the conversion of hydrogen peroxide to water and molecular oxygen, serving to protect cells from its toxic effects [[cite:PUB00012765]]. Hydrogen peroxide is produced as a consequence of oxidative cellular metabolism and can be converted to the highly reactive hydroxyl radical via transition metals, this radical being able to damage a wide variety of molecules within a cell, leading to oxidative stress and cell death. Catalases act to neutralise hydrogen peroxide toxicity, and are produced by all aerobic organisms ranging from bacteria to man. Most catalases are mono-functional, haem-containing enzymes, although there are also bifunctional haem-containing peroxidase/catalases ([interpro:IPR000763]) that are closely related to plant peroxidases, and non-haem, manganese-containing catalases ([interpro:IPR007760]) that are found in bacteria [[cite:PUB00015054]]. Based on a phylogenetic analysis, catalases can be classified into clade 1, 2 and 3. Clade 1 contains small subunit catalases from plants and a subset of bacteria; clade 2 contains large subunit catalases from fungi and a second subset of bacteria; and clade 3 contains small subunit catalases from bacteria, fungi, protists, animals, and plants [[cite:PUB00056180], [cite:PUB00027249]].</p> <p>This entry represents clades 1 and 3 of the mono-functional, haem-containing catalases.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Catalase activity | Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O. | ||
| Biological process | Response to oxidative stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. | ||
| Molecular function | Heme binding | Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Catalase; TAIR: AT4G35090.1 catalase 2; Swiss-Prot: sp|O48561|CATA4_SOYBN Catalase-4; TrEMBL-Plants: tr|A0PG71|A0PG71_LOTJA Catalase; Found in the gene: LotjaGi1g1v0436200 | 21 | ||
| – | Catalase; TAIR: AT4G35090.1 catalase 2; Swiss-Prot: sp|O48561|CATA4_SOYBN Catalase-4; TrEMBL-Plants: tr|A0PG71|A0PG71_LOTJA Catalase; Found in the gene: LotjaGi1g1v0436200 | 21 | ||
| – | Catalase; TAIR: AT4G35090.3 catalase 2; Swiss-Prot: sp|O48561|CATA4_SOYBN Catalase-4; TrEMBL-Plants: tr|A0PG71|A0PG71_LOTJA Catalase; Found in the gene: LotjaGi1g1v0436200 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd08154 | CDD | 1 | 33.33 |