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IPR024791

Source: InterPro

Description

IPR024791 is a Cytochrome c oxidase subunit III.

<p>Cytochrome c oxidase ([ec:7.1.1.9]) is the terminal enzyme of the respiratory chain of mitochondria and many aerobic bacteria. It catalyses the transfer of electrons from reduced cytochrome c to molecular oxygen:</p> <p><reaction> 4 cytochrome c<sup>+2</sup> + 4 H<sup>+</sup> + O<sub>2</sub> --> 4 cytochrome c<sup>+3</sup> + 2 H<sub>2</sub>O</reaction></p> <p>This reaction is coupled to the pumping of four additional protons across the mitochondrial or bacterial membrane [[cite:PUB00006599], [cite:PUB00033207]].</p> <p>Cytochrome c oxidase is an oligomeric enzymatic complex that is located in the mitochondrial inner membrane of eukaryotes and in the plasma membrane of aerobic prokaryotes. The core structure of prokaryotic and eukaryotic cytochrome c oxidase contains three common subunits, I, II and III. In prokaryotes, subunits I and III can be fused and a fourth subunit is sometimes found, whereas in eukaryotes there are a variable number of additional small polypeptidic subunits [[cite:PUB00006600]]. The functional role of subunit III is not yet understood.</p> <p>As the bacterial respiratory systems are branched, they have a number of distinct terminal oxidases, rather than the single cytochrome c oxidase present in the eukaryotic mitochondrial systems. Even though the cytochrome o complex oxidises quinol (ubiquinol) and does not catalyse the oxidation of reduced cytochrome c, they belong to the same haem-copper oxidase superfamily as cytochrome c oxidases. Members of this family share sequence similarities in all three core subunits: subunit I is the most conserved subunit, whereas subunit II is the least conserved [[cite:PUB00006601], [cite:PUB00006602], [cite:PUB00002253]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0015002
Molecular function Heme-copper terminal oxidase activity Catalysis of the four-electron reduction of dioxygen (O2) to water, coupled to generation of a proton electrochemical gradient across a membrane.
Subterm of
GO:0016020
Cellular component Membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
Subterm of
GO:0019646
Biological process Aerobic electron transport chain A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient.
Subterm of

Associated Lotus transcripts 12

Transcript Name Description Predicted domains Domain count
Lj1g3v1319360.1
– Cytochrome c oxidase subunit [Medicago truncatula] gi|357435997|ref|XP_003588274.1|
Domains
13
Lj3g3v2054320.1
– Cytochrome oxidase subunit III [Amborella trichopoda] gi|57639755|gb|AAW55720.1|
Domains
15
Ljmitog3v0000660.1
– RecName: Full=Cytochrome c oxidase subunit 3; AltName: Full=Cytochrome c oxidase polypeptide IIIgi|14121|emb|CAA35988.1| cytochrome c oxidase [Vicia faba] gi|416826|sp|Q03227.1|COX3_VICFA
Domains
16
LotjaGi1g1v0319900_LC.1
– Cytochrome c oxidase subunit 3; TAIR: AT2G07687.1 Cytochrome c oxidase, subunit III; Swiss-Prot: sp|P14853|COX3_SOYBN Cytochrome c oxidase subunit 3; TrEMBL-Plants: tr|A0A072TI35|A0A072TI35_MEDTR Cytochrome c oxidase subunit 3; Found in the gene: LotjaGi1g1v0319900_LC
Domains
20
LotjaGi1g1v0319900_LC.2
– Cytochrome c oxidase subunit 3; TAIR: AT2G07687.1 Cytochrome c oxidase, subunit III; Swiss-Prot: sp|P14853|COX3_SOYBN Cytochrome c oxidase subunit 3; TrEMBL-Plants: tr|A0A072TI35|A0A072TI35_MEDTR Cytochrome c oxidase subunit 3; Found in the gene: LotjaGi1g1v0319900_LC
Domains
13
LotjaGi1g1v0319900_LC.3
– Cytochrome c oxidase subunit 3; TAIR: AT2G07687.1 Cytochrome c oxidase, subunit III; Swiss-Prot: sp|P14853|COX3_SOYBN Cytochrome c oxidase subunit 3; TrEMBL-Plants: tr|A0A072TI35|A0A072TI35_MEDTR Cytochrome c oxidase subunit 3; Found in the gene: LotjaGi1g1v0319900_LC
Domains
13
LotjaGi1g1v0319900_LC.4
– Cytochrome c oxidase subunit 3; TAIR: AT2G07687.1 Cytochrome c oxidase, subunit III; Swiss-Prot: sp|P14853|COX3_SOYBN Cytochrome c oxidase subunit 3; TrEMBL-Plants: tr|A0A072TI35|A0A072TI35_MEDTR Cytochrome c oxidase subunit 3; Found in the gene: LotjaGi1g1v0319900_LC
Domains
13
LotjaGi3g1v0344400_LC.1
– Cytochrome c oxidase subunit 3; TAIR: AT2G07687.1 Cytochrome c oxidase, subunit III; Swiss-Prot: sp|P14853|COX3_SOYBN Cytochrome c oxidase subunit 3; TrEMBL-Plants: tr|A0A072TI35|A0A072TI35_MEDTR Cytochrome c oxidase subunit 3; Found in the gene: LotjaGi3g1v0344400_LC
Domains
13
LotjaGi3g1v0344400_LC.2
– Cytochrome c oxidase subunit 3; TAIR: AT2G07687.1 Cytochrome c oxidase, subunit III; Swiss-Prot: sp|P14853|COX3_SOYBN Cytochrome c oxidase subunit 3; TrEMBL-Plants: tr|A0A072TI35|A0A072TI35_MEDTR Cytochrome c oxidase subunit 3; Found in the gene: LotjaGi3g1v0344400_LC
Domains
13
LotjaGi3g1v0344400_LC.3
– Cytochrome c oxidase subunit 3; TAIR: AT2G07687.1 Cytochrome c oxidase, subunit III; Swiss-Prot: sp|P14853|COX3_SOYBN Cytochrome c oxidase subunit 3; TrEMBL-Plants: tr|A0A072TI35|A0A072TI35_MEDTR Cytochrome c oxidase subunit 3; Found in the gene: LotjaGi3g1v0344400_LC
Domains
13
LotjaGi3g1v0344400_LC.4
– Cytochrome c oxidase subunit 3; TAIR: AT2G07687.1 Cytochrome c oxidase, subunit III; Swiss-Prot: sp|P14853|COX3_SOYBN Cytochrome c oxidase subunit 3; TrEMBL-Plants: tr|A0A072TI35|A0A072TI35_MEDTR Cytochrome c oxidase subunit 3; Found in the gene: LotjaGi3g1v0344400_LC
Domains
13
LotjaGi3g1v0344400_LC.5
– Cytochrome c oxidase subunit 3; TAIR: AT2G07687.1 Cytochrome c oxidase, subunit III; Swiss-Prot: sp|P14853|COX3_SOYBN Cytochrome c oxidase subunit 3; TrEMBL-Plants: tr|A0A072TI35|A0A072TI35_MEDTR Cytochrome c oxidase subunit 3; Found in the gene: LotjaGi3g1v0344400_LC
Domains
13

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 8.33