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IPR025800 is a Calmodulin-lysine N-methyltransferase.
<p>Members of this family are calmodulin-lysine N-methyltransferase ([ec:2.1.1.60]) that catalyse the trimethylation of 'Lys-116' in calmodulin [[cite:PUB00058099]]. The enzyme is cytosolic and is found at high levels in tissues with high levels of calmodulin [[cite:PUB00058100]].</p> <p>Methyltransferases (EC [ec:2.1.1.-]) constitute an important class of enzymes present in every life form. They transfer a methyl group most frequently from S-adenosyl L-methionine (SAM or AdoMet) to a nucleophilic acceptor such as oxygen leading to S-adenosyl-L-homocysteine (AdoHcy) and a methylated molecule [[cite:PUB00057957], [cite:PUB00057958], [cite:PUB00054125]]. All these enzymes have in common a conserved region of about 130 amino acid residues that allow them to bind SAM [[cite:PUB00006319]]. The substrates that are methylated by these enzymes cover virtually every kind of biomolecules ranging from small molecules, to lipids, proteins and nucleic acids [[cite:PUB00057957], [cite:PUB00057958], [cite:PUB00006319]]. Methyltransferase are therefore involved in many essential cellular processes including biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing [[cite:PUB00057957], [cite:PUB00057958], [cite:PUB00054125]]. More than 230 families of methyltransferases have been described so far, of which more than 220 use SAM as the methyl donor.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Cytoplasm | All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | ||
| Molecular function | Calmodulin-lysine N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Methyltransferase, putative; TAIR: AT4G35987.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|B0K012|CMKMT_RAT Calmodulin-lysine N-methyltransferase; TrEMBL-Plants: tr|V7CGZ1|V7CGZ1_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0129000 | 8 | ||
| – | Methyltransferase, putative; TAIR: AT4G35987.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q6GQ33|CMKMT_XENLA Calmodulin-lysine N-methyltransferase; TrEMBL-Plants: tr|V7CGZ1|V7CGZ1_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0129000 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |