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IPR025984 is a dCTP pyrophosphatase 1.
<p>RS21-C6 proteins (also known as dCTP pyrophosphatases 1, DCTPP1) are NTP pyrophosphatases that structurally belong to the group of all-α NTP pyrophosphatases [[cite:PUB00079689], [cite:PUB00079704]]. They show significant sequence similarity to the dimeric 2-deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTP pyrophosphatase or dUTPase) and NTP-PPase MazG proteins [[cite:PUB00042205]]. However, unlike typical tandem-domain MazG proteins, RS21-C6 contains a single MazG-like domain and functions as a tetramer (a dimer of dimers) with a typical four-helical bundle. Divalent ions, such as Mg2+, are required for its pyrophosphatase activity [[cite:PUB00080470]]. Human dCTP pyrophosphatase 1 has been shown to be involved in nucleotide homoeostasis, contributing to detoxification of deoxycytidine triphosphate derivatives [[cite:PUB00080471]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Biological process | Nucleoside triphosphate catabolic process | The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. | ||
Molecular function | Nucleoside-triphosphate diphosphatase activity | Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | DCTP pyrophosphatase [Medicago truncatula] gi|357504985|ref|XP_003622781.1| | 11 | ||
– | PREDICTED: dCTP pyrophosphatase 1-like [Glycine max] gi|356514296|ref|XP_003525842.1| | 11 | ||
– | DCTP pyrophosphatase 1; TAIR: AT3G25400.1 dCTP pyrophosphatase-like protein; Swiss-Prot: sp|Q9H773|DCTP1_HUMAN dCTP pyrophosphatase 1; TrEMBL-Plants: tr|I3S801|I3S801_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0594300 | 8 | ||
– | DCTP pyrophosphatase 1; TAIR: AT3G25400.1 dCTP pyrophosphatase-like protein; Swiss-Prot: sp|Q32KY6|DCTP1_BOVIN dCTP pyrophosphatase 1; TrEMBL-Plants: tr|A0A0B2QJ90|A0A0B2QJ90_GLYSO dCTP pyrophosphatase 1; Found in the gene: LotjaGi4g1v0252400 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
cd11537 | CDD | 1 | 25.00 |