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IPR026017

Source: InterPro

Description

IPR026017 is a Lumazine-binding domain.

<p>The lumazine-binding domain is about 100 residues. In its C-terminal section, this domain contains a conserved motif [KR]-V-N-[LI]-E which has been proposed to be the binding site for lumazine (Lum) and some of its derivatives. Riboflavin synthase alpha chain (RS-alpha), which binds two molecules of Lum, has two perfect copies of this motif, while lumazine protein (LumP), which binds one molecule of Lum, has a Glu instead of Lys/Arg in the first position of the second copy of the motif. Similarly, yellow fluorescent protein (YFP), which binds to one molecule of FMN, also seems to have a potentially dysfunctional binding site by substitution of Gly for Glu in the last position of the first copy of the motif.</p> <p>The lumazine-binding domain of RS-alpha forms two Greek-key folds with the topology BBHBBBHB, where most of the substrate binding sites are located in β-strands (B) 4 and 5 and in helix (H) 2 [[cite:PUB00029900], [cite:PUB00025846], [cite:PUB00026878]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj0g3v0256909.1
– PREDICTED: riboflavin synthase-like [Cicer arietinum] gi|502146803|ref|XP_004506614.1|
Domains
12
LotjaGi3g1v0454500.1
– Riboflavin synthase; TAIR: AT2G20690.1 lumazine-binding family protein; Swiss-Prot: sp|A5DB51|RISA_PICGU Riboflavin synthase; TrEMBL-Plants: tr|A0A0L9V5H5|A0A0L9V5H5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0454500
Domains
13

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd00402 CDD 1 50.00