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IPR026147 is a Rab3GAP catalytic subunit, conserved domain.
<p>This entry represents a conserved domain found in the Rab3 GTPase-activating protein catalytic subunit (Rab3GAP1).</p> <p>Small G proteins of the Rab family are regulators of intracellular vesicle traffic. Their rate of GTP hydrolysis is enhanced by specific GTPase-activating proteins (GAPs) that switch G proteins to their inactive form [[cite:PUB00060687]]. Rab3GAP1 (catalytic subunit) has been shown to form a heterodimeric complex with Rab3GAP2 (the regulatory subunit), and this complex acts as a guanosine nucleotide exchange factor for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3GAP complex may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters [[cite:PUB00060112], [cite:PUB00060113]]. It also activates Rab18 and promotes autolysosome maturation through the Vps34 Complex I [[cite:PUB00098930]].</p> <p>Mutations in the Rab3GAP1/2 gene cause Warburg micro syndrome (WMS), a hereditary autosomal neuromuscular disorder [[cite:PUB00060114]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: rab3 GTPase-activating protein catalytic subunit-like isoform X1 [Cicer arietinum] gi|502129438|ref|XP_004500304.1| | 5 | ||
| – | PREDICTED: rab3 GTPase-activating protein catalytic subunit-like isoform X1 [Cicer arietinum] gi|502129438|ref|XP_004500304.1| | 4 | ||
| – | PREDICTED: rab3 GTPase-activating protein catalytic subunit-like isoform X1 [Cicer arietinum] gi|502129438|ref|XP_004500304.1| | 4 | ||
| – | Rab3 GTPase-activating protein catalytic subunit [Medicago truncatula] gi|357494597|ref|XP_003617587.1| | 8 | ||
| – | Rab3 GTPase-activating protein catalytic subunit [Medicago truncatula] gi|357494597|ref|XP_003617587.1| | 4 | ||
| – | Rab3 GTPase-activating protein catalytic subunit; TAIR: AT5G55060.1 Rab3 GTPase-activating protein catalytic subunit; Swiss-Prot: sp|P69735|RB3GP_RAT Rab3 GTPase-activating protein catalytic subunit (Fragments); TrEMBL-Plants: tr|G7K3L4|G7K3L4_MEDTR Rab3 GTPase-activating protein catalytic subunit; Found in the gene: LotjaGi1g1v0027100 | 5 | ||
| – | Rab3 GTPase-activating protein catalytic subunit; TAIR: AT5G58510.1 Rab3 GTPase-activating protein catalytic protein; Swiss-Prot: sp|Q642R9|RB3GP_XENLA Rab3 GTPase-activating protein catalytic subunit; TrEMBL-Plants: tr|A0A072UXW3|A0A072UXW3_MEDTR Rab3 GTPase-activating protein catalytic subunit; Found in the gene: LotjaGi6g1v0116800 | 5 | ||
| – | Rab3 GTPase-activating protein catalytic subunit; TAIR: AT5G58510.1 Rab3 GTPase-activating protein catalytic protein; Swiss-Prot: sp|Q642R9|RB3GP_XENLA Rab3 GTPase-activating protein catalytic subunit; TrEMBL-Plants: tr|A0A072UXW3|A0A072UXW3_MEDTR Rab3 GTPase-activating protein catalytic subunit; Found in the gene: LotjaGi6g1v0116800 | 5 | ||
| – | Rab3 GTPase-activating protein catalytic subunit; TAIR: AT5G58510.1 Rab3 GTPase-activating protein catalytic protein; Swiss-Prot: sp|Q15042|RB3GP_HUMAN Rab3 GTPase-activating protein catalytic subunit; TrEMBL-Plants: tr|A0A072UXW3|A0A072UXW3_MEDTR Rab3 GTPase-activating protein catalytic subunit; Found in the gene: LotjaGi6g1v0116800 | 5 | ||
| – | Rab3 GTPase-activating protein catalytic subunit; TAIR: AT5G55060.1 Rab3 GTPase-activating protein catalytic subunit; Swiss-Prot: sp|P69735|RB3GP_RAT Rab3 GTPase-activating protein catalytic subunit (Fragments); TrEMBL-Plants: tr|A0A151SBI2|A0A151SBI2_CAJCA Rab3 GTPase-activating protein catalytic subunit; Found in the gene: LotjaGi6g1v0157400 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 10.00 |