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IPR026872

Source: InterPro

Description

IPR026872 is a Protein farnesyltransferase subunit beta.

<p>Protein farnesyltransferase (FTase) is an enzyme responsible for the posttranslational modification (farnesylation) of proteins carrying a carboxy-terminal CaaX motif, including Ras, Ras homologues, and other small G proteins. FTase catalyses the transfer of a farnesyl moiety from farnesyl pyrophosphate to the cysteine at the CaaX motif, where a is a small aliphatic amino acid and X is the carboxy-terminal residue [[cite:PUB00061962], [cite:PUB00062311]]. Prenyltransferase employ a Zn2+ ion to alkylate a thiol group catalyzing the formation of thioether linkages between cysteine residues at or near the C terminus of protein acceptors and the C1 atom of isoprenoid lipids. FTase attaches a 15-carbon farnesyl group to the cysteine within the C-terminal CaaX motif of substrate proteins when X is Ala, Met, Ser, Cys or Gln [[cite:PUB00010618], [cite:PUB00026881], [cite:PUB00025021]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0005965
Cellular component Protein farnesyltransferase complex A protein complex that possesses protein farnesyltransferase activity.
Subterm of
GO:0018343
Biological process Protein farnesylation The covalent attachment of a farnesyl group to a protein.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj2g3v1014160.1
– PREDICTED: protein farnesyltransferase subunit beta-like [Cicer arietinum] gi|502090610|ref|XP_004489283.1|
Domains
9
LotjaGi2g1v0247100.1
– Farnesyl-protein transferase beta subunit; TAIR: AT5G40280.1 Prenyltransferase family protein; Swiss-Prot: sp|Q04903|FNTB_PEA Protein farnesyltransferase subunit beta; TrEMBL-Plants: tr|I1KCJ9|I1KCJ9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0247100
Domains
9

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd02893 CDD 1 50.00