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IPR027084

Source: InterPro

Description

IPR027084 is a Protein kinase Mps1 family, catalytic domain.

<p>This entry represents the catalytic domain of Mps1, which is in the C-terminal region [[cite:PUB00070318]].</p> <p>The Mps1 family of protein kinases is a critical regulator of genetic stability [[cite:PUB00083202], [cite:PUB00083203]]. In yeast, Mps1 is required for the spindle checkpoint and SPB duplication [[cite:PUB00083201]]. Human Mps1, also known as TTK, is required for proper chromosome alignment on the metaphase plate and for the fidelity of chromosome segregation, and might also have a role at centrosomes [[cite:PUB00070317]]. It is associated with cell proliferation and involved in mitotic cell cycle checkpoint control [[cite:PUB00062869], [cite:PUB00062871]]. In late mitosis, Mps1 is ubiquitinated by the APC/C and subsequently degraded [[cite:PUB00070319]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004712
Molecular function Protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
Subterm of
GO:0007093
Biological process Mitotic cell cycle checkpoint A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.
Subterm of
GO:0051304
Biological process Chromosome separation The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II).
Subterm of
Part of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj0g3v0307909.1
– Serine/threonine protein kinase [Medicago truncatula] gi|357461629|ref|XP_003601096.1|
Domains
18
Lj0g3v0307909.2
– Serine/threonine protein kinase [Medicago truncatula] gi|357461629|ref|XP_003601096.1|
Domains
18

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 50.00