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IPR027251

Source: InterPro

Description

IPR027251 is a Diacylglycerol O-acyltransferase 1.

<p>Diacylglycerol O-acyltransferase 1 (DGAT1) catalyses the final step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In plants, diacylglycerol O-acyltransferase 1 (DGAT1, TAG1) is a major enzyme for oil accumulation in seeds. It has complementary functions with PDAT1 acyltransferase that are essential for triacylglycerol synthesis and normal development of both seeds and pollen [[cite:PUB00063495], [cite:PUB00063492], [cite:PUB00063493], [cite:PUB00063494], [cite:PUB00063496]].</p> <p>In mammals, DGAT1 is a multifunctional acyltransferase capable of synthesizing diacylglycerol, retinyl, and wax esters in addition to triacylglycerol [[cite:PUB00063498]]. In liver, it plays a role in esterifying exogenous fatty acids to glycerol [[cite:PUB00063505]]. It also functions as the major acyl-CoA retinol acyltransferase in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders [[cite:PUB00063499]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004144
Molecular function Diacylglycerol O-acyltransferase activity Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
Subterm of
GO:0019432
Biological process Triglyceride biosynthetic process The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol.
Subterm of

Associated Lotus transcripts 4

Transcript Name Description Predicted domains Domain count
Lj4g3v2172770.1
– Diacylglycerol acyltransferase [Lotus japonicus] gi|57545061|gb|AAW51456.1|
Domains
13
Lj4g3v2172770.2
– Diacylglycerol acyltransferase [Lotus japonicus] gi|57545061|gb|AAW51456.1|
Domains
13
Lj6g3v1226310.1
– PREDICTED: diacylglycerol O-acyltransferase 1-like isoform X1 [Cicer arietinum] gi|502165138|ref|XP_004513435.1|
Domains
13
LotjaGi4g1v0311100.1
– O-acyltransferase; TAIR: AT2G19450.1 membrane bound O-acyl transferase (MBOAT) family protein; Swiss-Prot: sp|I1MSF2|DAT1B_SOYBN Diacylglycerol O-acyltransferase 1B; TrEMBL-Plants: tr|Q5I2P3|Q5I2P3_LOTJA O-acyltransferase; Found in the gene: LotjaGi4g1v0311100
Domains
13

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 25.00