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IPR004299 is a Membrane bound O-acyl transferase, MBOAT.
<p>The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue [[cite:PUB00007478]]. The structure of MBOAT has been revealed [[cite:PUB00095085]].</p> <p>This family includes Diacylglycerol O-acyltransferase 1 (DGAT1) and Lysophospholipid acyltransferase 7 (MBOAT7) from humans. DGAT1 catalyses the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates [[cite:PUB00099655]]. It also functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders [[cite:PUB00099655]]. MBOAT7 participates in the regulation of triglyceride metabolism through the phosphatidylinositol acyl-chain remodeling regulation [[cite:PUB00099654]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: lysophospholipid acyltransferase 1-like isoform X2 [Cicer arietinum] gi|502176104|ref|XP_004515799.1| | 8 | ||
| – | Membrane bound o-acyl transferase [Medicago truncatula] gi|357444731|ref|XP_003592643.1| | 8 | ||
| – | Membrane bound o-acyl transferase [Medicago truncatula] gi|357444731|ref|XP_003592643.1| | 8 | ||
| – | Membrane bound o-acyl transferase [Medicago truncatula] gi|357444731|ref|XP_003592643.1| | 8 | ||
| – | Diacylglycerol acyltransferase [Lotus japonicus] gi|57545061|gb|AAW51456.1| | 13 | ||
| – | Diacylglycerol acyltransferase [Lotus japonicus] gi|57545061|gb|AAW51456.1| | 13 | ||
| – | Membrane bound o-acyl transferase [Medicago truncatula] gi|357444731|ref|XP_003592643.1| | 8 | ||
| – | Membrane bound o-acyl transferase [Medicago truncatula] gi|357444731|ref|XP_003592643.1| | 9 | ||
| – | Membrane bound o-acyl transferase [Medicago truncatula] gi|357444731|ref|XP_003592643.1| | 9 | ||
| – | PREDICTED: diacylglycerol O-acyltransferase 1-like isoform X1 [Cicer arietinum] gi|502165138|ref|XP_004513435.1| | 13 | ||
| – | Lysophospholipid acyltransferase; TAIR: AT1G12640.1 MBOAT (membrane bound O-acyl transferase) family protein; Swiss-Prot: sp|F4IDU4|MBOA1_ARATH Lysophospholipid acyltransferase 1; TrEMBL-Plants: tr|A0A0R0FC11|A0A0R0FC11_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0220100 | 8 | ||
| – | O-acyltransferase; TAIR: AT1G57600.1 MBOAT (membrane bound O-acyl transferase) family protein; Swiss-Prot: sp|Q09758|YA71_SCHPO Putative membrane-bound O-acyltransferase C24H6.01c; TrEMBL-Plants: tr|A0A151RPQ6|A0A151RPQ6_CAJCA Putative membrane-bound O-acyltransferase C24H6.01c; Found in the gene: LotjaGi4g1v0303600 | 8 | ||
| – | O-acyltransferase; TAIR: AT1G57600.1 MBOAT (membrane bound O-acyl transferase) family protein; Swiss-Prot: sp|Q09758|YA71_SCHPO Putative membrane-bound O-acyltransferase C24H6.01c; TrEMBL-Plants: tr|A0A151RPQ6|A0A151RPQ6_CAJCA Putative membrane-bound O-acyltransferase C24H6.01c; Found in the gene: LotjaGi4g1v0303600 | 8 | ||
| – | O-acyltransferase; TAIR: AT2G19450.1 membrane bound O-acyl transferase (MBOAT) family protein; Swiss-Prot: sp|I1MSF2|DAT1B_SOYBN Diacylglycerol O-acyltransferase 1B; TrEMBL-Plants: tr|Q5I2P3|Q5I2P3_LOTJA O-acyltransferase; Found in the gene: LotjaGi4g1v0311100 | 13 | ||
| – | O-acyltransferase; TAIR: AT1G57600.1 MBOAT (membrane bound O-acyl transferase) family protein; Swiss-Prot: sp|Q09758|YA71_SCHPO Putative membrane-bound O-acyltransferase C24H6.01c; TrEMBL-Plants: tr|A0A151RPQ6|A0A151RPQ6_CAJCA Putative membrane-bound O-acyltransferase C24H6.01c; Found in the gene: LotjaGi5g1v0339000 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 6.67 |