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IPR027512

Source: InterPro

Description

IPR027512 is a Eukaryotic translation initiation factor 3 subunit A.

<p>Eukaryotic translation initiation factor 3 subunit A is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. However, the subunit is not required for the general function of eIF3 in translation initiation [[cite:PUB00064776]]. It may play a role in regulating translation of a subset of mRNAs and in regulating cell cycle progression and cell proliferation [[cite:PUB00064777]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0005852
Cellular component Eukaryotic translation initiation factor 3 complex A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj1g3v4551350.1
– PREDICTED: eukaryotic translation initiation factor 3 subunit A-like [Glycine max] gi|356572345|ref|XP_003554329.1|
Domains
9
LotjaGi1g1v0698800.1
– Eukaryotic translation initiation factor 3 subunit A; TAIR: AT4G11420.1 eukaryotic translation initiation factor 3A; Swiss-Prot: sp|Q9LD55|EIF3A_ARATH Eukaryotic translation initiation factor 3 subunit A; TrEMBL-Plants: tr|A0A0S3RYH0|A0A0S3RYH0_PHAAN Eukaryotic translation initiation factor 3 subunit A; Found in the gene: LotjaGi1g1v0698800
Domains
13
LotjaGi1g1v0698800.2
– Eukaryotic translation initiation factor 3 subunit A; TAIR: AT4G11420.1 eukaryotic translation initiation factor 3A; Swiss-Prot: sp|Q9LD55|EIF3A_ARATH Eukaryotic translation initiation factor 3 subunit A; TrEMBL-Plants: tr|A0A0S3RYH0|A0A0S3RYH0_PHAAN Eukaryotic translation initiation factor 3 subunit A; Found in the gene: LotjaGi1g1v0698800
Domains
13

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 33.33