Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR027517

Source: InterPro

Description

IPR027517 is a Deoxyhypusine hydroxylase.

<p>Deoxyhypusine hydroxylase ([ec:1.14.99.29]) catalyses the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor [[cite:PUB00064786]]. In Drosophila melanogaster, it is essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis [[cite:PUB00064785]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0008612
Biological process Peptidyl-lysine modification to peptidyl-hypusine The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine.
Subterm of
GO:0019135
Molecular function Deoxyhypusine monooxygenase activity Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj1g3v4483390.1
– PREDICTED: deoxyhypusine hydroxylase-like [Glycine max] gi|356504995|ref|XP_003521278.1|
Domains
11
LotjaGi1g1v0711400.1
– Deoxyhypusine hydroxylase; TAIR: AT3G58180.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q94JW0|DOHH_ARATH Deoxyhypusine hydroxylase; TrEMBL-Plants: tr|V7D020|V7D020_PHAVU Deoxyhypusine hydroxylase; Found in the gene: LotjaGi1g1v0711400
Domains
12

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 50.00