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IPR027521 is a U6 snRNA phosphodiesterase 1.
<p>Proteins in this family are phosphodiesterases responsible for trimming the poly (U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA [[cite:PUB00064790], [cite:PUB00100252]].</p> <p>In Saccharomyces cerevisiae, Usb1 is an essential protein that localises to the nucleus and mitochondria [[cite:PUB00016470]]. Usb1 overexpression can compensate for specific respiratory defects of an oxa1 yeast mutant [[cite:PUB00066979]].</p> <p>In humans, Usb1 is localised to the nucleus and is involved in the 2',3'-cyclic phosphate formation at the 3' end of U6 snRNA [[cite:PUB00064790]]. The human protein has been shown to degrade both oligo(U) and oligo(A) tails at the 3' end of U6 snRNA [[cite:PUB00065818]]. Its crystal structure has been solved and shows a globular α-β-type architecture [[cite:PUB00065818]]. Mutation in Usb1 is linked to poikiloderma with neutropenia (PN), a genodermatosis characterised by poikiloderma, pachyonychia and chronic neutropenia [[cite:PUB00066977], [cite:PUB00066978]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Nuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids. | ||
| Biological process | U6 snRNA 3'-end processing | Any process involved in forming the mature 3' end of a U6 snRNA molecule. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: UPF0406 protein C16orf57-like isoform 1 [Glycine max] gi|356495919|ref|XP_003516818.1| | 7 | ||
| – | U6 snRNA phosphodiesterase; TAIR: AT5G51170.1 U6 snRNA phosphodiesterase-like protein; Swiss-Prot: sp|Q5I0I5|USB1_RAT U6 snRNA phosphodiesterase; TrEMBL-Plants: tr|A0A151U0J9|A0A151U0J9_CAJCA U6 snRNA phosphodiesterase; Found in the gene: LotjaGi1g1v0601900 | 6 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |