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IPR027528 is a Eukaryotic translation initiation factor 3 subunit M.
<p>This entry represents the eukaryotic translation initiation factor 3 subunit M (eIF3m) and the COP9/Signalosome and eIF3 complex-shared subunit 1 (CIF-1) from roundworms. eIF3m is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome [[cite:PUB00005773]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Molecular function | Translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. | ||
Cellular component | Cytoplasm | All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | ||
Cellular component | Eukaryotic translation initiation factor 3 complex | A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | PREDICTED: eukaryotic translation initiation factor 3 subunit M-like [Glycine max] gi|356534937|ref|XP_003536007.1| | 12 | ||
– | Eukaryotic translation initiation factor 3 subunit M; TAIR: AT5G15610.2 Proteasome component (PCI) domain protein; Swiss-Prot: sp|Q54KZ8|EIF3M_DICDI Eukaryotic translation initiation factor 3 subunit M; TrEMBL-Plants: tr|A0A072U6R5|A0A072U6R5_MEDTR Eukaryotic translation initiation factor 3 subunit M; Found in the gene: LotjaGi2g1v0267200 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
SSF48371 | SUPERFAMILY | 1 | 50.00 |