Description

IPR028356 is a UDP-glucose 6-dehydrogenase, eukaryotic type.

<p>UDP-glucose 6-dehydrogenase is involved in the biosynthesis of UDP-glucuronic acid (UDP-GlcA), a critical precursor for glycan synthesis. In vertebrates it is involved in the biosynthesis of matrix glycosaminoglycans (hyaluronan, chondroitin sulfate, and heparan sulfan) which play significant roles in signaling, inflammation, morphogenesis, cancer growth and matrix organisation [[cite:PUB00056285]]. In plants, it provides nucleotide sugars for cell-wall polymers [[cite:PUB00068160]]. Proteins in this entry include human UDP-glucose 6-dehydrogenase [[cite:PUB00056285], [cite:PUB00068213]].</p> <p>This entry represents the UDP-glucose 6-dehydrogenase mainly from eukaryotes. However, subsets of bacterial proteins can be found in this entry. Most of the bacterial type of the UDP-glucose 6-dehydrogenase can be found in [interpro:IPR028357].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 19

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: