Description

IPR001732 is a UDP-glucose/GDP-mannose dehydrogenase, N-terminal.

<p>The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate [[cite:PUB00002546], [cite:PUB00003005]].</p> <p>The enzymes have a wide range of functions. In plants UDP-glucose dehydrogenase, [ec:1.1.1.22], is an important enzyme in the synthesis of hemicellulose and pectin [[cite:PUB00009417]], which are the components of newly formed cell walls; while in zebrafish UDP-glucose dehydrogenase is required for cardiac valve formation [[cite:PUB00009418]]. In Xanthomonas campestris, a plant pathogen, UDP-glucose dehydrogenase is required for virulence [[cite:PUB00009419]].</p> <p>This entry represents the N-terminal NAD(+)-binding domain. Structural studies indicate that this domain forms an α-β structure containing the six-stranded parallel β sheet characteristic of the dinucleotide binding Rossman fold [[cite:PUB00028366], [cite:PUB00027324]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 20

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: