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IPR028363 is a DNA-directed RNA polymerase, subunit RPB6.
<p>Subunit RPB6/RPABC2 is a common component of eukaryotic RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, respectively. In RNA polymerase II (Pol II), RPB6/RPABC2 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds [[cite:PUB00068177]].</p> <p>In addition to RNA polymerases I, II, and III, the essential RNA polymerases present in all eukaryotes, plants have two additional nuclear RNA polymerases, abbreviated as Pol IV and Pol V, that play nonredundant roles in siRNA-directed DNA methylation and gene silencing. Pol IV and Pol V are composed of subunits that are paralogous or identical to the 12 subunits of Pol II, including subunit RPB6 [[cite:PUB00068178]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA-directed 5'-3' RNA polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. | ||
| Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. | ||
| Cellular component | RNA polymerase II, core complex | RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. | ||
| Biological process | Transcription, DNA-templated | The cellular synthesis of RNA on a template of DNA. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC2-like [Glycine max] gi|356535896|ref|XP_003536478.1| | 15 | ||
| – | PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC2-like [Glycine max] gi|356535896|ref|XP_003536478.1| | 15 | ||
| – | DNA-directed RNA polymerase II family protein; TAIR: AT5G51940.1 RNA polymerase Rpb6; Swiss-Prot: sp|Q9FJ98|RPD6A_ARATH DNA-directed RNA polymerases II, IV and V subunit 6A; TrEMBL-Plants: tr|I3RZV1|I3RZV1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0057700 | 17 | ||
| – | DNA-directed RNA polymerase II family protein; TAIR: AT5G51940.1 RNA polymerase Rpb6; Swiss-Prot: sp|Q9FJ98|RPD6A_ARATH DNA-directed RNA polymerases II, IV and V subunit 6A; TrEMBL-Plants: tr|I3RZV1|I3RZV1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0343700 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |