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IPR028472

Source: InterPro

Description

IPR028472 is a Eyes absent family.

<p>Members of the eye absent (EYA) family were originally characterised in fly eye development. EYA proteins are both transcriptional activators and tyrosine phosphatases [[cite:PUB00014199], [cite:PUB00068736]], and have been shown to dephosphorylate H2AX, promoting repair and cell survival in the response to DNA damage [[cite:PUB00068479]]. EYA proteins (EYA1-4) are normally expressed early in development [[cite:PUB00068480], [cite:PUB00068481]]. Their phosphatase activity regulates Six1-Dach-Eya transcriptional effects in precursor cell proliferation and survival in mammalian organogenesis [[cite:PUB00068482]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004725
Molecular function Protein tyrosine phosphatase activity Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subterm of

Associated Lotus transcripts 4

Transcript Name Description Predicted domains Domain count
Lj3g3v2003920.1
– PREDICTED: eyes absent homolog 4-like [Glycine max] gi|356512012|ref|XP_003524715.1|
Domains
4
Lj3g3v2003920.2
– PREDICTED: eyes absent homolog 4-like [Glycine max] gi|356512012|ref|XP_003524715.1|
Domains
4
Lj3g3v2003930.1
– PREDICTED: eyes absent homolog 4-like [Cicer arietinum] gi|502152633|ref|XP_004509018.1|
Domains
2
LotjaGi4g1v0187900.1
– Eyes absent; TAIR: AT2G35320.1 eyes absent-like protein; Swiss-Prot: sp|O95677|EYA4_HUMAN Eyes absent homolog 4; TrEMBL-Plants: tr|A0A0B2P1X9|A0A0B2P1X9_GLYSO Eyes absent like 4; Found in the gene: LotjaGi4g1v0187900
Domains
9

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TIGR01658 TIGRFAM 1 25.00