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IPR028884

Source: InterPro

Description

IPR028884 is a tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit.

<p>This entry represents tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit Trm82 and its homologues, wuho from flies and WDR4 from humans.</p> <p>In Saccharomyces cerevisiae, Trm82 is the non-catalytic subunit of the tRNA methyltransferase complex which consists of Trm8 and Trm82 [[cite:PUB00049689], [cite:PUB00057963]]. It is essential for the enzyme activity and may function in regulating the the Trm8 protein [[cite:PUB00049689]].</p> <p>In humans, WDR4 forms the tRNA methyltransferase complex with METTL1 (Trm8 homologue). It is required to stabilise and induce conformational changes of the catalytic subunit METTL1 [[cite:PUB00017356]]. It is required for the formation of N7-methylguanine at position 46 (m7G46) in tRNA [[cite:PUB00017356], [cite:PUB00100516]] and also for the formation of N7-methylguanine at internal sites in a subset of mRNAs [[cite:PUB00100516]]. WDR4 is also involved in the methylation of a specific subset of miRNAs, such as let-7 [[cite:PUB00100514]]. Independently of METTL1, it also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1 [[cite:PUB00100515]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0036265
Biological process RNA (guanine-N7)-methylation The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an RNA molecule.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0717100.1
– TRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit; TAIR: AT1G03110.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|Q7ZY78|WDR4_XENLA tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wdr4; TrEMBL-Plants: tr|I1JNW2|I1JNW2_SOYBN tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit; Found in the gene: LotjaGi1g1v0717100
Domains
15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF50978 SUPERFAMILY 1 100.00