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IPR028945 is a Get1 family.
<p>In budding yeasts, Golgi to ER traffic protein 1 (Get1) is a component of the Golgi to ER traffic (GET) complex, which is composed of Get1, Get2 and Get3. The GET complex mediates posttranslational insertion of newly synthesised tail-anchored (TA) proteins to the endoplasmic reticulum (ER) membrane.The GET complex is composed of the homodimeric Get3 ATPase and its heterooligomeric receptor, Get1/2. Get1 stabilises an open dimer conformation of Get3 [[cite:PUB00069738]].</p> <p>In metazoa, the homologue to Get1 is known as tail-anchored protein insertion receptor WRB, which is a receptor for ASNA1/TRC40 (Get3 in yeast) [[cite:PUB00069739]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Tail-anchored membrane protein insertion into ER membrane | A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Uncharacterized protein isoform 1 [Theobroma cacao] gi|508698771|gb|EOX90667.1| | 9 | ||
| – | Tail-anchored protein insertion receptor WRB; TAIR: AT4G16444.1 tail-anchored protein insertion receptor WRB-like protein; Swiss-Prot: sp|O00258|WRB_HUMAN Tail-anchored protein insertion receptor WRB; TrEMBL-Plants: tr|I3SMP1|I3SMP1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0135800 | 9 | ||
| – | Tail-anchored protein insertion receptor WRB; TAIR: AT4G16444.1 tail-anchored protein insertion receptor WRB-like protein; Swiss-Prot: sp|O00258|WRB_HUMAN Tail-anchored protein insertion receptor WRB; TrEMBL-Plants: tr|I3SMP1|I3SMP1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0135800 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 33.33 |