Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR030230

Source: InterPro

Description

IPR030230 is a GPN-loop GTPase 1.

<p>GPN-loop GTPase 1 (Gpn1) belongs to the GPN-loop GTPase family [[cite:PUB00042299]]. It is also known as Npa3 in budding yeasts, QQT2 in plants and XAB1 in humans.</p> <p>Npa3 has GTPase activity that is essential for its binding to RNA polymerase II (RNAPII) and the nuclear localisation of RNAPII [[cite:PUB00072007]].</p> <p>The small GTPase QQT2 is essential for the correct formation of the tangential divisions in early embryos. This protein associates with microtubules during mitosis and may play a role in the positioning of the division plane [[cite:PUB00101696]].</p> <p>XAB1 is a cytoplasmic GTPase involved in nuclear localisation of DNA repair protein XPA [[cite:PUB00072010]].</p> <p>This entry also includes archaeal GPN-loop GTPases, such as PYRAB14380 from Pyrococcus abyssi [[cite:PUB00042299]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003924
Molecular function GTPase activity Catalysis of the reaction: GTP + H2O = GDP + phosphate.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
Lj4g3v2263890.1
– GPN-loop GTPase [Medicago truncatula] gi|357443887|ref|XP_003592221.1|
Domains
12

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 100.00