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IPR032054 is a DNA replication factor Cdt1, C-terminal.
<p>In eukaryotic replication licensing, Cdt1 plays a key role by recruiting the MCM2-7 complex onto the origin of chromosome. This entry represents the C-terminal domain of Cdt1 which is the most conserved region of Cdt1, essential for licensing and directly interacts with the MCM2-7 complex [[cite:PUB00066010]]. This region contains a WHD (winged helix domain), a typical DNA recognition motif [[cite:PUB00097388]]. The winged-helix fold is conserved throughout several other licensing factors, suggesting that they evolved from a common ancestor. In mouse Cdt1, the main role of the WH motif is to interact with MCM2-7 rather than with the DNA, as other winged-helix domains.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: CDT1-like protein b-like isoform X1 [Cicer arietinum] gi|502163312|ref|XP_004512799.1| | 10 | ||
| – | PREDICTED: CDT1-like protein a, chloroplastic-like [Cicer arietinum] gi|502115034|ref|XP_004495110.1| | 12 | ||
| – | CDT1-like protein a, chloroplastic; TAIR: AT3G54710.1 CDT1-like protein B; Swiss-Prot: sp|Q9M1S9|CDT1B_ARATH CDT1-like protein b; TrEMBL-Plants: tr|A0A0B2QXX1|A0A0B2QXX1_GLYSO CDT1-like protein a, chloroplastic; Found in the gene: LotjaGi2g1v0174200 | 10 | ||
| – | CDT1-like protein a, chloroplastic; TAIR: AT3G54710.1 CDT1-like protein B; Swiss-Prot: sp|Q9M1S9|CDT1B_ARATH CDT1-like protein b; TrEMBL-Plants: tr|A0A0B2QXX1|A0A0B2QXX1_GLYSO CDT1-like protein a, chloroplastic; Found in the gene: LotjaGi2g1v0174200 | 10 | ||
| – | CDT1-like protein a, chloroplastic; TAIR: AT2G31270.1 CDT1-like protein A; Swiss-Prot: sp|Q9SJW9|CDT1A_ARATH CDT1-like protein a, chloroplastic; TrEMBL-Plants: tr|A0A072VLQ6|A0A072VLQ6_MEDTR DNA replication factor CDT1-like protein; Found in the gene: LotjaGi5g1v0179700 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |