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IPR032465

Source: InterPro

Description

IPR032465 is a 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase.

<p>2-amino-3-carboxymuconate-6-semialdehyde decarboxylase, also known as picolinate carboxylase or ACMSD, is a member of the amidohydrolase superfamily involved in tryptophan metabolism [[cite:PUB00076371], [cite:PUB00076373]]. It converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMSD has medical importance as its substrate ACMS is unstable and dehydrates to quinolinic acid (QUIN, QA), not only a key precursor of NAD, but also a potent neurotoxin [[cite:PUB00076372]]. Elevated levels of QUIN have been observed in several neuropsychiatric and neurodegenerative conditions [[cite:PUB00076368], [cite:PUB00076369], [cite:PUB00076370]].</p> <p>The entry also includes decarboxylases OrsB, MacB and YanB, and salicylate decarboxylase.</p> <p>YanB is a decarboxylase and part of the gene cluster that mediates the biosynthesis of yanuthone D, a fungal isoprenoid epoxycyclohexenone that acts as an antibiotic against fungi and bacteria [[cite:PUB00083261]]. Salicylate decarboxylase has been shown to catalyse both the decarboxylation of salicylic acid to produce phenol, and the carboxylation of phenol to form salicylic acid [[cite:PUB00086569]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0016831
Molecular function Carboxy-lyase activity Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0532000.1
– 4-sulfomuconolactone hydrolase; TAIR: AT2G35450.1 catalytic/ hydrolase; Swiss-Prot: sp|A6XIG6|SLMH_HYDIT 4-sulfomuconolactone hydrolase; TrEMBL-Plants: tr|I3T8F7|I3T8F7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0532000
Domains
14

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SignalP-TM SignalP_GRAM_NEGATIVE 1 100.00