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IPR032852 is a DNA oxidative demethylase ALKBH2.
<p>AlkB is a dioxygenase that repairs alkylation damage to DNA and RNA [[cite:PUB00076916]]. AlkB homologues (ABHs) are found in all multicellular organisms, as well as in many bacteria and fungi, and some viruses [[cite:PUB00095244]]. Nine mammalian AlkB homologues exist (ALKBH1-8, FTO), but only a subset functions as DNA/RNA repair enzymes [[cite:PUB00076917]].</p> <p>This entry represents AlkB homologue 2 (ALKBH2, ABH2), which has a strong preference for double-stranded DNA [[cite:PUB00076916]]. Together with alkyl-N-adenine-DNA glycosylase, comprises the cellular defence against 1,N(6)-ethenoadenine lesions [[cite:PUB00076920]]. ABH2 also has an important role in maintaining ribosomal DNA gene integrity and transcription [[cite:PUB00076919]]. This entry also includes uncharacterised bacterial homologues.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: alpha-ketoglutarate-dependent dioxygenase alkB homolog 2-like [Cicer arietinum] gi|502079759|ref|XP_004486359.1| | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF51197 | SUPERFAMILY | 1 | 100.00 |