Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR027450 is a Alpha-ketoglutarate-dependent dioxygenase AlkB-like.
<p>This superfamily brings together catalytic domains found in Alpha-ketoglutarate-dependent dioxygenase AlkB-like DNA/RNA demethylases.</p> <p>AlkB is a DNA repair enzyme that removes methyl adducts and some larger alkylation lesions from endocyclic positions on purine and pyrimidine bases. It is a dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron [[cite:PUB00064960], [cite:PUB00064961]].</p> <p>The catalytic core of AlkB is homologous to other Fe-2OG dioxygenases [[cite:PUB00064580], [cite:PUB00076935]]. Two discrete global conformations have been observed for AlkB, differing in accessibility of a putative oxygen-diffusion tunnel [[cite:PUB00053097]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Transport protein sec31 isoform 1 [Theobroma cacao] gi|508702955|gb|EOX94851.1| | 9 | ||
| – | PREDICTED: probable alpha-ketoglutarate-dependent dioxygenase ABH6-like [Glycine max] gi|356559947|ref|XP_003548257.1| | 9 | ||
| – | PREDICTED: alpha-ketoglutarate-dependent dioxygenase AlkB homolog [Glycine max] gi|356573293|ref|XP_003554797.1| | 10 | ||
| – | Alkylated DNA repair protein alkB-like protein [Medicago truncatula] gi|357484481|ref|XP_003612528.1| | 11 | ||
| – | PREDICTED: alkylated DNA repair protein alkB homolog 8-like isoform X2 [Cicer arietinum] gi|502161954|ref|XP_004512340.1| | 14 | ||
| – | PREDICTED: alkylated DNA repair protein alkB homolog 8 [Vitis vinifera] gi|225437314|ref|XP_002263866.1| | 9 | ||
| – | Alpha-ketoglutarate-dependent dioxygenase alkB-like protein [Medicago truncatula] gi|357470119|ref|XP_003605344.1| | 15 | ||
| – | Alpha-ketoglutarate-dependent dioxygenase alkB-like protein [Medicago truncatula] gi|357470119|ref|XP_003605344.1| | 13 | ||
| – | Hydroxyproline-rich glycoprotein-like protein [Arabidopsis thaliana] gi|18394153|ref|NP_563957.1| | 6 | ||
| – | Alkylated DNA repair protein alkB-like protein [Medicago truncatula] gi|357462995|ref|XP_003601779.1| | 9 | ||
| – | PREDICTED: RNA demethylase ALKBH5-like [Cicer arietinum] gi|502125179|ref|XP_004498830.1| | 9 | ||
| – | Transport protein sec31 isoform 1 [Theobroma cacao] gi|508702955|gb|EOX94851.1| | 9 | ||
| – | PREDICTED: alpha-ketoglutarate-dependent dioxygenase alkB homolog 2-like [Cicer arietinum] gi|502079759|ref|XP_004486359.1| | 9 | ||
| – | PREDICTED: RNA demethylase ALKBH5-like [Cicer arietinum] gi|502076939|ref|XP_004485500.1| | 10 | ||
| – | RNA-binding (RRM/RBD/RNP motifs) family protein; TAIR: AT4G02485.1 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein; Swiss-Prot: sp|Q9UT12|YLW2_SCHPO Uncharacterized protein P8A3.02c; TrEMBL-Plants: tr|I1M6V8|I1M6V8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0038300 | 10 | ||
| – | Alpha-ketoglutarate-dependent dioxygenase AlkB like; TAIR: AT3G14160.1 2-oxoglutarate-dependent dioxygenase family protein; Swiss-Prot: sp|P05050|ALKB_ECOLI Alpha-ketoglutarate-dependent dioxygenase AlkB; TrEMBL-Plants: tr|A0A0L9TEQ1|A0A0L9TEQ1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0799900 | 11 | ||
| – | RNA-binding (RRM/RBD/RNP motifs) family protein; TAIR: AT4G20350.2 oxidoreductase; Swiss-Prot: sp|Q3KRA9|ALKB6_HUMAN Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6; TrEMBL-Plants: tr|I3SBA3|I3SBA3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0165400 | 9 | ||
| – | RNA-binding (RRM/RBD/RNP motifs) family protein; TAIR: AT1G31600.1 RNA-binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|Q07G10|ALKB8_XENTR Alkylated DNA repair protein alkB homolog 8; TrEMBL-Plants: tr|I1L5A9|I1L5A9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0351300 | 16 | ||
| – | RNA-binding (RRM/RBD/RNP motifs) family protein; TAIR: AT1G31600.1 RNA-binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|Q07G10|ALKB8_XENTR Alkylated DNA repair protein alkB homolog 8; TrEMBL-Plants: tr|I1L5A9|I1L5A9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0351300 | 16 | ||
| – | Alpha-ketoglutarate-dependent dioxygenase AlkB; TAIR: AT5G01780.2 2-oxoglutarate-dependent dioxygenase family protein; Swiss-Prot: sp|P05050|ALKB_ECOLI Alpha-ketoglutarate-dependent dioxygenase AlkB; TrEMBL-Plants: tr|A0A1J7IJV0|A0A1J7IJV0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0203300 | 16 | ||
| – | Alpha-ketoglutarate-dependent dioxygenase AlkB; TAIR: AT5G01780.5 2-oxoglutarate-dependent dioxygenase family protein; Swiss-Prot: sp|Q5EAC5|ZN410_BOVIN Zinc finger protein 410; TrEMBL-Plants: tr|A0A1J7IJV0|A0A1J7IJV0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0203300 | 14 | ||
| – | 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase-like protein; TAIR: AT2G17970.1 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein; Swiss-Prot: sp|Q3TSG4|ALKB5_MOUSE RNA demethylase ALKBH5; TrEMBL-Plants: tr|A0A0R0GNF3|A0A0R0GNF3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0049300 | 10 | ||
| – | 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase-like protein; TAIR: AT2G17970.1 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein; Swiss-Prot: sp|Q08BA6|ALKB5_DANRE RNA demethylase ALKBH5; TrEMBL-Plants: tr|A0A0R0GNF3|A0A0R0GNF3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0049300 | 10 | ||
| – | 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase-like protein; TAIR: AT2G17970.1 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein; Swiss-Prot: sp|Q08BA6|ALKB5_DANRE RNA demethylase ALKBH5; TrEMBL-Plants: tr|A0A0R0GNF3|A0A0R0GNF3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0049300 | 10 | ||
| – | Alpha-ketoglutarate-dependent dioxygenase alkB; TAIR: AT1G11780.1 oxidoreductase, 2OG-Fe(II) oxygenase family protein; Swiss-Prot: sp|Q9SA98|ALKBH_ARATH Alpha-ketoglutarate-dependent dioxygenase alkB; TrEMBL-Plants: tr|I3T319|I3T319_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0097800 | 10 | ||
| – | Alpha-ketoglutarate-dependent dioxygenase alkB like 3; TAIR: AT2G22260.6 oxidoreductase, 2OG-Fe(II) oxygenase family protein; Swiss-Prot: sp|Q9SIE0|ALKB2_ARATH DNA oxidative demethylase ALKBH2; TrEMBL-Plants: tr|I1L044|I1L044_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0282200 | 10 | ||
| – | Alpha-ketoglutarate-dependent dioxygenase alkB like 3; TAIR: AT2G22260.6 oxidoreductase, 2OG-Fe(II) oxygenase family protein; Swiss-Prot: sp|Q9SIE0|ALKB2_ARATH DNA oxidative demethylase ALKBH2; TrEMBL-Plants: tr|I1L044|I1L044_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0282200 | 9 | ||
| – | 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase-like protein; TAIR: AT4G36090.2 oxidoreductase, 2OG-Fe(II) oxygenase family protein; Swiss-Prot: sp|D3ZKD3|ALKB5_RAT RNA demethylase ALKBH5; TrEMBL-Plants: tr|A0A151T7Y1|A0A151T7Y1_CAJCA Alkylated DNA repair protein alkB isogeny 5; Found in the gene: LotjaGi6g1v0360100 | 11 | ||
| – | 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase-like protein; TAIR: AT4G36090.1 oxidoreductase, 2OG-Fe(II) oxygenase family protein; Swiss-Prot: sp|Q3TSG4|ALKB5_MOUSE RNA demethylase ALKBH5; TrEMBL-Plants: tr|A0A151T7Y1|A0A151T7Y1_CAJCA Alkylated DNA repair protein alkB isogeny 5; Found in the gene: LotjaGi6g1v0360100 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 3.45 |