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IPR033179 is a Phosphatidylserine decarboxylase, prokaryotic type 2.
<p>Although most bacterial PSDs belong to type 1, some are classified in type 2. They are found mainly in Clostridium, Fusobacterium and Chlamydia. This entry represents the type 2 subfamily.</p> <p>Phosphatidylserine decarboxylase plays a pivotal role in the synthesis of phospholipid by the mitochondria. The substrate phosphatidylserine is synthesized extramitochondrially and must be translocated to the mitochondria prior to decarboxylation [[cite:PUB00008264]]. Phosphatidylserine decarboxylases [ec:4.1.1.65] is responsible for conversion of phosphatidylserine to phosphatidylethanolamine and plays a central role in the biosynthesis of aminophospholipids [[cite:PUB00008265]].</p> <p>Phosphatidylserine decarboxylases (PSDs) have been classified in two types. Type I PSDs include enzymes of eukaryotic mitochondria and bacterial origin which contain the amino acid sequence LGST as a characteristic motif. Type II PSDs are found in the endomembrane system of eukaryotes and contain a typical GGST motif. These characteristic motifs are considered as autocatalytic cleavage sites where proenzymes are split into alpha and beta subunits [[cite:PUB00078006]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Phosphatidylserine decarboxylase activity | Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine. | ||
| Biological process | Phospholipid biosynthetic process | The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Phosphatidylserine decarboxylase proenzyme; TAIR: AT5G57190.1 phosphatidylserine decarboxylase 2; Swiss-Prot: sp|F4KAK5|PSD2_ARATH Phosphatidylserine decarboxylase proenzyme 2; TrEMBL-Plants: tr|I1KUF4|I1KUF4_SOYBN Phosphatidylserine decarboxylase proenzyme 2; Found in the gene: LotjaGi6g1v0355200 | 28 | ||
| – | Phosphatidylserine decarboxylase proenzyme; TAIR: AT5G57190.1 phosphatidylserine decarboxylase 2; Swiss-Prot: sp|F4KAK5|PSD2_ARATH Phosphatidylserine decarboxylase proenzyme 2; TrEMBL-Plants: tr|I1KUF5|I1KUF5_SOYBN Phosphatidylserine decarboxylase proenzyme 2; Found in the gene: LotjaGi6g1v0355200 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00051 | CDD | 1 | 50.00 |