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IPR033177 is a Phosphatidylserine decarboxylase, bacterial/eukaryotic.
<p>This entry represents Phosphatidylserine decarboxylase proenzyme and similar sequences mainly found in eukaryotes and bacteria. Phosphatidylserine decarboxylase (PSD, [ec:4.1.1.65]) is synthesised as a single chain precursor. Generation of the pyruvoyl active site from a Ser is coupled to cleavage of a Gly-Ser bond between the larger (beta) and smaller (alpha chains). This enzyme catalyses the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). It is an integral membrane protein.</p> <p>Phosphatidylserine decarboxylases (PSDs) have been classified in two types. Type I PSDs include enzymes of eukaryotic mitochondria and bacterial origin which contain the amino acid sequence LGST as a characteristic motif. Type II PSDs are found in the endomembrane system of eukaryotes and contain a typical GGST motif. These characteristic motifs are considered as autocatalytic cleavage sites where proenzymes are split into alpha and beta subunits [[cite:PUB00078006]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Phosphatidylserine decarboxylase activity | Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine. | ||
| Biological process | Phospholipid biosynthetic process | The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: phosphatidylserine decarboxylase proenzyme-like isoform X3 [Cicer arietinum] gi|502160315|ref|XP_004511705.1| | 11 | ||
| – | PREDICTED: phosphatidylserine decarboxylase proenzyme-like, partial [Glycine max] gi|356540538|ref|XP_003538745.1| | 5 | ||
| – | PREDICTED: C2 domain-containing protein C31G5.15-like [Glycine max] gi|356525902|ref|XP_003531560.1| | 5 | ||
| – | PREDICTED: phosphatidylserine decarboxylase proenzyme 3-like [Cicer arietinum] gi|502077078|ref|XP_004485545.1| | 21 | ||
| – | PREDICTED: C2 domain-containing protein C31G5.15-like [Glycine max] gi|356525902|ref|XP_003531560.1| | 5 | ||
| – | PREDICTED: C2 domain-containing protein C31G5.15-like [Glycine max] gi|356525902|ref|XP_003531560.1| | 5 | ||
| – | Phosphatidylserine decarboxylase proenzyme; TAIR: AT4G16700.1 phosphatidylserine decarboxylase 1; Swiss-Prot: sp|Q84V22|PSD1_ARATH Phosphatidylserine decarboxylase proenzyme 1, mitochondrial; TrEMBL-Plants: tr|A0A0S3T6A6|A0A0S3T6A6_PHAAN Phosphatidylserine decarboxylase proenzyme 1, mitochondrial; Found in the gene: LotjaGi2g1v0421700 | 11 | ||
| – | Phosphatidylserine decarboxylase proenzyme; TAIR: AT5G57190.1 phosphatidylserine decarboxylase 2; Swiss-Prot: sp|F4KAK5|PSD2_ARATH Phosphatidylserine decarboxylase proenzyme 2; TrEMBL-Plants: tr|I1KUF4|I1KUF4_SOYBN Phosphatidylserine decarboxylase proenzyme 2; Found in the gene: LotjaGi6g1v0355200 | 28 | ||
| – | Phosphatidylserine decarboxylase proenzyme; TAIR: AT5G57190.1 phosphatidylserine decarboxylase 2; Swiss-Prot: sp|F4KAK5|PSD2_ARATH Phosphatidylserine decarboxylase proenzyme 2; TrEMBL-Plants: tr|I1KUF5|I1KUF5_SOYBN Phosphatidylserine decarboxylase proenzyme 2; Found in the gene: LotjaGi6g1v0355200 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00051 | CDD | 1 | 11.11 |