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IPR033246

Source: InterPro

Description

IPR033246 is a DNA-binding protein BIN4.

<p>BIN4 (also known as MIDGET) is a plant-specific, DNA binding protein that acts as a component of the plant DNA topoisomerase VI complex. BIN4 is required for endoreduplication [[cite:PUB00078256]]. Loss of BIN4 triggers an ATM- and ATR-dependent DNA damage response in postmitotic cells, and this response coincides with the upregulation of the cyclin B1;1 gene, suggesting a functional link between DNA damage response and endocycle control [[cite:PUB00078256], [cite:PUB00078647]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003690
Molecular function Double-stranded DNA binding Interacting selectively and non-covalently with double-stranded DNA.
Subterm of
GO:0009330
Cellular component DNA topoisomerase complex (ATP-hydrolyzing) Complex that possesses DNA topoisomerase (ATP-hydrolyzing) activity.
Subterm of
GO:0042023
Biological process DNA endoreduplication Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj0g3v0127239.1
– PREDICTED: DNA-binding protein BIN4-like isoform X2 [Cicer arietinum] gi|502136688|ref|XP_004502788.1|
Domains
4
LotjaGi1g1v0302400.1
– DNA-binding protein BIN4; TAIR: AT5G24630.11 double-stranded DNA binding protein; Swiss-Prot: sp|Q9FLU1|BIN4_ARATH DNA-binding protein BIN4; TrEMBL-Plants: tr|A0A1J7IRE2|A0A1J7IRE2_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0302400
Domains
3
LotjaGi2g1v0438800_LC.1
– DNA-binding protein BIN4; TAIR: AT5G24630.5 double-stranded DNA binding protein; Swiss-Prot: sp|Q9FLU1|BIN4_ARATH DNA-binding protein BIN4; TrEMBL-Plants: tr|A0A151SGA4|A0A151SGA4_CAJCA DNA-binding protein BIN4; Found in the gene: LotjaGi2g1v0438800_LC
Domains
3

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 33.33