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IPR033309 is a Crossover junction endonuclease Mus81.
<p>Budding yeast Mus81 complexes with Mms4 (EME1 or EME2 in humans) to form a structure-specific endonuclease that targets branched DNA structures with a 5'-end at the branch nick [[cite:PUB00078392], [cite:PUB00078395]]. Its typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions [[cite:PUB00078394], [cite:PUB00078393]].</p> <p>Similar to MUS81-EME1, human MUS81-EME2 cleaves 3'-flaps, replication forks and nicked Holliday junctions, and exhibits limited endonuclease activity with intact Holliday junctions. However, MUS81-EME2 can also cleave a variety of DNA structures including D-loop recombination intermediates and nicked duplex [[cite:PUB00078396], [cite:PUB00078397]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: crossover junction endonuclease MUS81-like [Cicer arietinum] gi|502165003|ref|XP_004513369.1| | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 100.00 |